BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

JPK Instruments AG Reports on Single Molecule Research at IISER Pune in India Using AFM and CellHesion Techniques


5/21/2013 9:11:03 AM

Staying up-to-date has never been simpler. Sign up for the free GenePool newsletter today!

Berlin, 21st May 2013: JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the work of the Nano-Mechanics Laboratory at the Indian Institute of Science Education & Research (IISER) Pune, India.

The Nano-mechanics group develops and uses novel techniques to understand molecular processes and has recently developed new instrumentation in the fields of single molecule force spectroscopy and correlation spectroscopy. There are three main areas of research: protein folding using AFM, measuring the mechanical properties of supported lipid bilayers and following the mechanical response of nano-confined fluids. This last area is performed on home-built instruments.

Assistant Professor, Shivprasad Patil, leads the research team. He describes his work and reasons for selecting JPK's NanoWizard® AFM platform and CellHesion™ modules to help speed his research efforts. "For our protein folding research, we modified our JPK system to enable the detection of the change in fluorescence intensity as the protein unfolds. We will measure the autocorrelation of such intensity fluctuations as the protein visits its complex energy landscape when clamped at different loads. We have modified the AFM to excite the tip-sample junction and collect the light from single molecule under a given load. In the future, we plan to perform autocorrelation of fluorescence intensities as the protein fluctuates across various conformations."

Making the choice to buy from JPK was quite simple: "One of the important things about JPK instrument is its ability to provide access to the optical tip-sample junction. This helped us in modifying it for our need to attach fluorescence correlation spectroscopy to it."

Describing the lipid bilayer mechanical property studies, Professor Patil continued: "Straining supported bi-layers and measuring the stress generated in lipid-bi-layer systems in important from the perspective of understanding the processes of endocytosis and exocytosis in intracellular transport. We are using JPK's CellHesion module to measure bending rigidity of lipid bi-layers. This allowed us to pull on tethers formed from supported bi-layers by 50 to 100 microns. Having this 100 micron pulling range is most important to our work and appears unique when compared to competitive systems."

For more details about JPK's NanoWizard, the CellHesion module and applications for the bio and nano sciences, please contact JPK on +49 30533112070, visit the web site: http://www.jpk.com/ or see more on Facebook: http://www.jpk.com/ or see more on Facebook: www.jpk.com/facebook.



Help employers find you! Check out all the jobs and post your resume.


Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES