Intracellular Bacterial Communities in Cystitis; Rifapentine Cures TB in Mouse Model; and More

A study published this week in the open access journal PLoS Medicine presents convincing evidence that intracellular bacterial communities (IBCs) commonly exist in women with bladder infections and may contribute to the recurrence of these infections. In mice it has already been established that Escherichia coli (E coli), a type of bacterium that causes urinary tract infections, can avoid the immune system by invading cells lining the bladder, replicate and ultimately re-infect the urinary tract. The existence of IBCs in this new study suggests that a similar cycle may occur in people and that perhaps longer treatment with antibiotics that kill bacteria inside human cells may be necessary for some patients.

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