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INTEGROMICS Release: Publication in Cell Describes Novel Polyadenylation Genome-Wide Profiling, Achieved Using Integromics 'Seqsolve' Next Generation Sequencing Software


1/10/2011 11:04:18 AM

Granada and Madrid, Spain and Philadelphia, PA, U.S., January 10, 2011 – Integromics, a market leader in IT solutions provision for life sciences in the field of genomics and proteomics, today announces the publication of a paper in the journal Cell highlighting a novel genome wide profiling of polyadenylation events in human and yeast performed with Direct RNA Sequencing.

The data analysis used the recently introduced SeqSolve Next Generation Sequencing (NGS) functional bioinformatics analysis software and Direct RNA Sequencing. The discovered novel polyadenylation genomic sites and signals will provide a unique reference resource for the scientific community.

The published results demonstrate the crucial importance of appropriate bioinformatics software in maximizing the value of the data produced by high-end last generation high-throughput sequencing instruments. This is important in a market environment, where the cost of sequencing is plummeting, but the revolution is limited by a bottleneck at the level of downstream functional data analysis and interpretation.

The SeqSolve analysis software is an independent, multi-organism sequencing solution, performing tertiary level analyzes for biologically relevant results. It features the exclusive Click and GO(R) technology for seamless transcriptome profiling automation and quality control, besides the TIBCO Spotfire(R) platform for scientific data visualization and extended downstream analysis.

“The article in Cell follows an article published in Nature in July 2010 about the initial SeqSolve analysis and demonstrates both our commitment to and the value of our SeqSolve software,” said Dr. Michael J. McManus, CEO, Integromics. “Integromics developed the software to perform high-throughput sequencing data analysis and to discover previously unidentified mechanisms, events, signals and correlations in the genomes of human and other organisms.”

The Cell article, entitled ‘Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation’ (Vol. 143, Issue 6, p. 1018, http://www.cell.com/abstract/S0092-8674%2810%2901300-0), was co-authored by Dr. Sylvain Foissac from Integromics, SL.; Drs. Bino John, A. Paula Monaghan, Elane Fishilevich and Sang Woo Kim, from the University of Pittsburgh School of Medicine; and Drs. Fatih Ozsolak, Philipp Kapranov and Patrice Milos from Helicos BioSciences Corporation.

An initial analysis using SeqSolve was published in July 2010 in the journal Nature (Kapranov P. et al. Nature, July 29, 2010).

SeqSolve is now available on free trial at http://www.integromics.com/ngs.

About Integromics(R) S.L

INTEGROMICS, S.L. provides IT solutions for life sciences in the areas of genomics and proteomics. In the post-genomic era, Integromics S.L. offers state-of-the-art products, services and training in two strategic areas: data management/integration and intelligent data analysis. The company has developed a network of collaborators both in industry and academia to provide complete technological solutions that will help our clients to achieve their goals. Integromics(R) S.L. was founded in 2002 and is based in Granada, Spain, with offices in Madrid, Spain. Integromics, Inc., a wholly owned subsidiary that was established in 2007 is based in Philadelphia, PA. For more information, visit http://www.integromics.com/

Lynne Chapman ANDREW LLOYD & ASSOCIATES http://www.ala.com lynne@ala.com

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