BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Intarcia Therapeutics, Inc. Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes


9/12/2011 11:11:13 AM

HAYWARD, Calif., Sept. 12, 2011 /PRNewswire/ -- Intarcia Therapeutics, Inc. announced today the presentation of three clinical abstracts on ITCA 650 (DUROS® subcutaneous continuous delivery of exenatide) for the treatment of type 2 diabetes at the 47th Annual Meeting of the European Association for the Study of Diabetes in Lisbon, Portugal. All three presentations are scheduled for Wednesday, September 14 in the Lisbon International Fair Convention Center.

(Logo: http://photos.prnewswire.com/prnh/20050301/SFTU126LOGO)

The first presentation, covering final 48 week results of the ITCA 650 phase 2 study will be delivered by Julio Rosenstock, MD, a principal investigator in the study from the Dallas Diabetes and Endocrine Center in Dallas, TX.

Abstract # 77

Oral Presentation Session OP 13 GLP-1 receptor agonists

Wednesday, September 14, 2011 from 10:45 -- 12:15 in Roma Hall

Long-term, injection-free treatment with ITCA 650, a continuous subcutaneous delivery of exenatide via DUROS® device, leads to stable glycaemic and weight control for 48 weeks in metformin-treated type 2 diabetes

K. Luskey(1), J. Rosenstock(2), T. Alessi(1), R.R. Henry(3)

(1) Intarcia Therapeutics, Hayward, CA, USA, (2) Dallas Diabetes and Endocrine Center, Dallas, TX, USA, (3) University of California at San Diego, La Jolla, CA, USA.

Two other ITCA 650 presentations will occur in the poster session Wednesday afternoon. Thomas Alessi, PhD, Intarcia's Vice President, Development will present the results of a patient satisfaction study applied to the ITCA 650 phase 2 study and Kenneth Luskey, MD, Intarcia's Chief Medical Officer will present an assessment of the pharmacokinetics and pharmacodynamics observed in the ITCA 650 phase 2 study.

Poster Session PS 063 GLP-1 receptor agonists: new drugs and new formulations

Wednesday, September 14, 2011 from 12:30 -- 1:30 in the Poster Hall

Abstract # 789

Improved patient satisfaction with ITCA 650 vs exenatide injections in subjects with metformin-treated type 2 diabetes

T. Alessi(1), R.R. Henry(2), J. Rosenstock(3), K. Luskey(1)

(1) Intarcia Therapeutics, Hayward, CA, USA, (2) University of California at San Diego, La Jolla, CA, USA, (3) Dallas Diabetes and Endocrine Center, Dallas, TX, USA.

Abstract # 790

Pharmacokinetic and pharmacodynamic assessments with ITCA 650, a continuous subcutaneous delivery of exenatide via DUROS® device, in type 2 diabetes

J. Dahms(1), Y. Chandrasekher(1), R. Fielding(2), R. Zhou(3), R.R. Henry(4), J. Rosenstock(5), T. Alessi(1), K. Luskey(1)

(1) Intarcia Therapeutics, Hayward, CA, USA, (2) Biologistic Services, Boulder, CO, USA, (3) Medpace, Cincinnati, OH, USA, (4) University of California at San Diego, La Jolla, CA, USA, (5) Dallas Diabetes and Endocrine Center, Dallas, TX, USA

About ITCA 650

ITCA 650 therapy for type 2 diabetes consists of DUROS continuous subcutaneous delivery of exenatide. The DUROS delivery technology comprises the DUROS device, a matchstick-size, miniature osmotic pump that is inserted subcutaneously to provide continuous and consistent drug therapy. Intarcia's proprietary formulation technology that maintains stability of therapeutic proteins and peptides at human body temperatures for extended periods of time.

The DUROS technology can deliver up to a full year of therapy from a single ITCA 650 insertion. Unlike other extended delivery technologies, such as polymers or albumin fusions, DUROS delivery allows for steady state drug delivery upon placement and near immediate cessation of therapy, if required. ITCA 650 is an investigational new drug and is not currently approved by any regulatory authority. Exenatide, the active agent in ITCA 650, has been approved in the U.S., Europe and many other markets and is currently marketed as a twice-daily self-injection therapy for type 2 diabetes. Intarcia's robust IP portfolio protects ITCA 650 through 2027.

About Type 2 Diabetes

According to a June 2011Lancet publication by Danaei and colleagues, an estimated 347 million adults worldwide had diabetes in 2008 and that number is expected to rise to 472 million by 2030. A significant portion of cases results from striking increases in countries like China and India, accounting for 138 million cases, the USA and Russia, accounting for 36 million cases, and an additional 42 million cases in Brazil, Pakistan, Indonesia, Japan and Mexico. Pre-diabetes, or impaired glucose tolerance (IGT), a condition that often leads to diabetes, affects a population that is roughly double that of the current diabetes population. The World Health Organization estimates deaths resulting from diabetes will double between 2005 and 2030 and estimates the global cost of diabetes to have exceeded $400 billion in 2010. United Healthcare expects spending on diabetes and diabetes-related care to reach $500 billion by 2020 in the US alone and projects the cumulative cost of diabetes care to reach $3.4 trillion over the next decade.

About Intarcia

Intarcia Therapeutics, Inc. is a biopharmaceutical company developing therapies to ensure enhanced treatment outcome by optimizing patient adherence and improving the efficacy, convenience and tolerability of drug therapies. Intarcia's drug development expertise and competitive edge are demonstrated by its abilities to stabilize proteins and peptides at above body temperature and to deliver them in a constant and consistent manner via its proprietary DUROS drug delivery platform. Intarcia is pursuing a clinical stage development program for type 2 diabetes and has other programs for weight regulation to control obesity.

Intarcia and its logo are registered trademarks of Intarcia Therapeutics, Inc. DUROS is a registered trademark of ALZA Corporation licensed to Intarcia Therapeutics, Inc. in certain fields.

SOURCE Intarcia Therapeutics, Inc.



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES