Implantation Of The CARMAT Heart In A 3rd Patient At The Georges Pompidou European Hospital

Paris, April 28, 2015 CARMAT (FR0010907956, ALCAR, PEA-PME eligible), the designer and developer of the world's most advanced total artificial heart project, aiming to provide a therapeutic alternative for people suffering from end-stage heart failure, today confirms the implantation of the CARMAT bioprosthesis in a 3rd patient.

This 3rd implantation of the CARMAT heart was carried out on April 8th by the Georges Pompidou European Hospital team ("Hôpital européen Georges Pompidou - Assistance Publique-Hôpitaux de Paris") and went smoothly.

The feasibility study is scheduled to include a total of four patients suffering from irreversible bi-ventricular heart failure who are in an immediate life-threatening situation.

The criteria for success notably include the patient's 30-day survival following the implant and the functional recovery of their vital organs.

Marcello Conviti, Chief Executive Officer of CARMAT, says: "We would like to congratulate the entire Georges Pompidou European Hospital team for again proving their medical prowess by carrying out the implantation of a 3rd CARMAT heart in a human. We are also very pleased with the state of health of the 2nd patient, who is now enjoying a normal life again after returning home at the beginning of the year."

The Company would like to remind readers that, in accordance with good clinical practice and subject to regulatory obligations or specific circumstances, it is not planning to publish any information on the interim results of this ongoing feasibility study.

About CARMAT: the world's most advanced total artificial heart project

A credible response to end-stage heart failure: CARMAT aims to eventually provide a response to a major public health issue associated with heart disease, the world's leading cause of death: chronic and acute heart failure. By pursuing the development of its total artificial heart, CARMAT intends to overcome the well-known shortfall in heart transplants for the tens of thousands of people suffering from irreversible end-stage heart failure, the most seriously affected of the 20 million patients with this progressive disease in Europe and the United States.

The result of combining two types of unique expertise: the medical expertise of Professor Carpentier, known throughout the world for inventing Carpentier-Edwards® heart valves, which are the most used in the world, and the technological expertise of Airbus Group, world aerospace leader.

Imitating the natural heart: given its size, the choice of structural materials and its innovative physiological functions, CARMAT's total artificial heart could, assuming the necessary clinical trials are successful, potentially benefit the lives of thousands of patients a year with no risk of rejection and with a good quality of life.

A project leader acknowledged at a European level: with the backing of the European Commission, CARMAT has been granted the largest subsidy ever given to an SME by Bpifrance; a total of €33 million.

Strongly committed, prestigious founders and shareholders: Airbus Group, Professor Alain Carpentier, the Centre Chirurgical Marie Lannelongue, Truffle Capital, a leading European venture capital firm, and the thousands of institutional and individual shareholders who have placed their trust in CARMAT.

For more information: www.carmatsa.com

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