Impaired Coordination of Brain Activity in Autism Involves Local, as Well as Long-Range, Signaling, Massachusetts General Hospital Study

A study based at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) finds that the local functional connectivity of the brain – the extent to which the activity of within a small brain region appears to be coordinated – is reduced in individuals with autism spectrum disorders (ASD). Although it has been recognized for several years that functional connectivity between separate areas of the brain was reduced in ASD, it had been assumed that local functional connectivity was actually higher in the brains of autistic individuals.

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