BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Immune System Therapeutics Limited Drug Shows Positive Response in Patients with Multiple Myeloma Blood Cancer


6/17/2011 6:39:22 AM

Sydney, Australia, 17 June 2011; Australian monoclonal antibody company, Immune System Therapeutics Limited (IST), today announced it would double patient recruitment in its Phase II trial for a breakthrough antibody treatment for terminal blood cancer.

The trial expansion in Australia follows a positive review of safety and efficacy data by an independent Data Monitoring Committee (DMC) of data from the first six patients treated with the new monoclonal antibody therapy at The Alfred Hospital in Melbourne under the supervision of principal investigator and head of Malignant Haematology and Stem Cell Transplantation, Professor Andrew Spencer.

The DMC recommended that recruitment under the trial be expanded to include up to 27 patients suffering from the life threatening disease multiple myeloma.

The promising new drug, called MDX-1097, is a genetically engineered antibody that binds specifically to a target protein found on the cell surface of some types of blood cancer. Researchers anticipate the antibody will potentially reduce the number of cancerous cells in multiple myeloma patients and improve patient health and wellbeing. Laboratory studies have shown that the antibody works with the patient’s immune system to induce death of their multiple myeloma cancer cells.

IST Chief Executive Officer, Mr Alan Liddle, said, “We are very excited to have achieved this important milestone towards our goal of developing an effective treatment for patients suffering from this debilitating blood cancer. We intend to initiate another hospital site in Australia to accelerate recruitment as soon as possible.”

“Simultaneously we are putting in place the appropriate licensing structure to enable the further clinical development and regulatory processes needed to commercialise this promising new medical treatment. We are in discussion with a number of global pharmaceutical companies,” Mr Liddle added.

IST Head of Clinical Development, Dr Rosanne Dunn, said “One patient has shown a very good decrease in blood levels of both of the abnormal or “monoclonal” proteins produced by the myeloma cells. No adverse effects or drug related side effects have been observed in any patients as the antibody only targets and kills the kappa myeloma cells and doesn’t bind to any normal cells or tissue.

"The response we are seeing is rare in cancer treatment and an indication that the antibody specifically targets cancer cells and not normal cells. Our current Phase II trial builds on the results of the Phase I trial in 12 patients at The Alfred hospital which showed the drug was safe and well tolerated and no drug related toxicities were observed,” Dr Dunn said.

Multiple myeloma is a debilitating terminal disease, with an estimated patient population of over 150,000 worldwide. The disease typically occurs in older patients and is responsible for two per cent of all cancer deaths in the United States every year.

IST is undertaking additional preclinical work using the same antibody platform technology to target other diseases with major unmet clinical needs.

For more information please contact:

Alan Liddle

CEO

Tel: 02 9514 7434

Dr Rosanne Dunn

Head of Clinical Development

Tel: 02 9514 4060

About Immune Systems Therapeutics

Immune Systems Therapeutics (IST) is a private bio-therapeutic company commercialising a range of promising new antibody drugs to treat human blood cancers and autoimmune diseases. The company’s unique therapies target a range of common blood cancers known as B cell malignancies and autoimmune diseases. IST has extensive and robust patents covering a new class of drugs targeting blood cancers and autoimmune diseases that are potentially safer, less toxic and more effective than current standard chemotherapy treatments. IST’s business plan is to license its drugs to international pharmaceutical companies for regulatory approval, production and sales. For more information please visit www.istl.com.au



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES