Idera Pharmaceuticals, Inc. Announces Presentation of Positive Data From Phase 2 Trial of TLR 7 and 9 Antagonist in Patients With Moderate-to-Severe Plaque Psoriasis
Staying up-to-date has never been simpler. Sign up for the free GenePool newsletter today!
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Idera Pharmaceuticals (NASDAQ: IDRA) today announced presentation of data from its randomized, double-blind, placebo-controlled Phase 2 trial that showed improvements from baseline of up to 90% in Psoriasis Area Severity Index (PASI) scores in patients with moderate to severe plaque psoriasis following four weeks of treatment with the Toll-like Receptor (TLR) antagonist IMO-3100. Additionally, analysis of biopsy samples collected from patients during the Phase 2 trial indicated that PASI score improvements were associated with significant improvement of psoriasis disease-associated gene profile, including downregulation of activated genes in the IL-17 pathway, which is central to the pathogenesis of psoriasis. Treatment with IMO-3100 was well tolerated, with no treatment-related discontinuations. The presentation entitled “IMO-3100, an antagonist of Toll-like receptor (TLR) 7 and 9, demonstrates clinical activity in psoriasis patients with 4 weeks of treatment in a Phase 2a trial” was made by Alexa Kimball M.D., M.P.H., Vice Chair, Department of Dermatology at Massachusetts General Hospital, Boston, and an investigator in the trial, at the International Investigative Dermatology meeting in Edinburgh, Scotland May 8th through 13th, 2013.
Help employers find you! Check out all the jobs and post your resume.
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Idera Pharmaceuticals (NASDAQ: IDRA) today announced presentation of data from its randomized, double-blind, placebo-controlled Phase 2 trial that showed improvements from baseline of up to 90% in Psoriasis Area Severity Index (PASI) scores in patients with moderate to severe plaque psoriasis following four weeks of treatment with the Toll-like Receptor (TLR) antagonist IMO-3100. Additionally, analysis of biopsy samples collected from patients during the Phase 2 trial indicated that PASI score improvements were associated with significant improvement of psoriasis disease-associated gene profile, including downregulation of activated genes in the IL-17 pathway, which is central to the pathogenesis of psoriasis. Treatment with IMO-3100 was well tolerated, with no treatment-related discontinuations. The presentation entitled “IMO-3100, an antagonist of Toll-like receptor (TLR) 7 and 9, demonstrates clinical activity in psoriasis patients with 4 weeks of treatment in a Phase 2a trial” was made by Alexa Kimball M.D., M.P.H., Vice Chair, Department of Dermatology at Massachusetts General Hospital, Boston, and an investigator in the trial, at the International Investigative Dermatology meeting in Edinburgh, Scotland May 8th through 13th, 2013.
Help employers find you! Check out all the jobs and post your resume.