BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

GlycoVaxyn AG and a Harvard University Affiliated Hospital Receive USD 3.4 Million National Institutes of Health (NIH) Grant for Staphylococcus aureus Vaccine Development


5/4/2010 6:59:45 AM

SCHLIEREN, Switzerland & BOSTON--(BUSINESS WIRE)--GlycoVaxyn AG, a leader in the development of innovative bioconjugate vaccines, and Professor Jean Lee, principal investigator at the Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, announced today that they have received a USD 3.4 million NIH grant to finance preclinical development of a novel Staphylococcus aureus vaccine. S. aureus is a major cause of hospital-based infections.

Using GlycoVaxyn’s proprietary technology, staphylococcal surface polysaccharides will be conjugated in vivo to conserved protein antigens from S. aureus. The efficacy of this novel bioconjugate vaccine will then be evaluated in different animal models of S. aureus infection.

“GlycoVaxyn’s first generation S. aureus bioconjugate vaccine has shown protective efficacy in preclinical studies. The new generation vaccine is expected to give broader protection against a variety of S. aureus strains,” declared Dr. Jean Lee.

GlycoVaxyn and the Brigham and Women’s Hospital have a long standing collaboration on this project, and the NIH funding will accelerate the development of potential vaccine candidates.

In parallel to this innovative approach, GlycoVaxyn, which started Phase I clinical trials with a bioconjugate vaccine against Shigella dysenteriae early this year, is expecting to start a clinical trial with its first generation S. aureus vaccine by late 2011.

“Our bioconjugation technology allows us a very flexible and powerful approach to multivalent vaccine development, coupling polysaccharide to protein antigens in a strictly controlled way,” said Dr. Michael Wacker, CSO and founder of GlycoVaxyn. “This grant confirms the potential of this approach and will allow extensive preclinical evaluation of the novel vaccine.”

Nosocomial infections, often caused by S. aureus, are a major concern in hospital settings accounting for estimated USD 5 billion in additional costs. In 2007, there were approximately 2 million infections and 100,000 associated deaths in U.S. hospitals alone, making nosocomial infections one of the leading overall causes of death. Prevention of nosocomial infections is therefore an important task for healthcare providers to reduce the burden of disease.

A conjugate vaccine, used to immunize against serious bacterial infections, is created by linking a sugar antigen to a carrier protein molecule. The current process to obtain such a structure is often very complex, unreliable and expensive. GlycoVaxyn’s S. aureus vaccine consists of capsular polysaccharide type 5 or 8 of S. aureus conjugated to a staphylococcal protein carrier. It is produced using GlycoVaxyn’s novel technology that allows the synthesis of these complex immunogenic bioconjugates via a biological process in E. coli, which makes the production more effective and controlled. Conjugate vaccines are largely used to prevent important invasive diseases such as bacteremia (bloodstream infection), pneumonia, and meningitis, with the market leader achieving nearly USD 3 billion in annual sales in 2009.

About GlycoVaxyn

GlycoVaxyn is developing a broad portfolio of novel conjugate vaccines against common severe bacterial infections based on its unique, proprietary in-vivo glycosylation platform. With this platform, the company can develop and produce immunogenic glycoproteins in a simplified biological process that circumvents many of the difficulties involved in current methods. The lead conjugates in development are vaccines directed against Shigella dysenteriae, to prevent serious intestinal infections, and hospital acquired Staphylococcus aureus. The company also has an active program against N. meningitidis. GlycoVaxyn, a spin-out of the Swiss Federal Institute of Technology (ETH), is based in Schlieren, near Zurich, Switzerland. For further information, visit www.glycovaxyn.com.

Contact:

GlycoVaxyn AG Philippe Dro, +41 44 733 8581 philippe.dro@glycovaxyn.com or Halsin Partners Mike Sinclair, +44 20 7084 5955 msinclair@halsin.com

Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES