BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Genovis Release: FragIT(TM) - Some Things are Simple


4/20/2011 9:31:43 AM

April 20, 2011 -- Genovis launches FragIT Kit which include one spin column for fragmentation of IgG and one spin column for capturing the Fc part isolating the intact F(ab’)2. The kit provides a quick protocol for a superior yield of F(ab’)2 or Fab fragments in a scalable format.

FragIT Kit contains one spin column for IgG fragmentation (FragIT spin column) and one Fc capturing spin column. The kit is available in three standard sizes; 0.5, 10 and 100 mg. Genovis provides other format on request.

FragIT spin columns come prefilled with FabRICATOR® enzyme immobilized on agarose that allow for easy and quick fragmentation of IgG into F(ab’)2 and Fc fragment. Fragmentation of IgG is typically associated with low yield, heterogeneity of the produced fragments and a cumbersome and time- consuming process. All these shortcomings can now be solved using FragIT columns. After elution from the FragIT column, F(ab’)2 and Fc fragments are separated using a Fc capturing spin column. This column contains anti Fc IgG molecules conjugated to agarose. The F(ab)2 fragments are easily eluted at a very high yield.

If Fab fragments is a more desirable format the conversion into Fab fragments is performed in one quick reduction step, for further information see web site www.genovis.com/Fab2_to_Fab

FabRICATOR®

Genovis has developed FabRICATOR, to rapidly generate precise F(ab’)2 fragments. FabRICATOR is a partially modified and his-tagged IdeS enzyme* that cleaves IgG in a singular defined site below the hinge region leaving an intact F(ab?)2 and two residual Fc fragments. The yield of the reaction is high and the enzyme does not further digest the resulting products. *IdeS is a highly substrate specific cysteine protease originating from Streptococcus pyogenes.

Read more: www.genovis.com/FragIT-Kit

For additional information please contact:

Fredrik Olsson

Phone: +4646-10 12 33

fredrik.olsson@genovis.com

www.genovis.com



Read at BioSpace.com

Genovis
 
 

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES