PALO ALTO, Calif., April 5 /PRNewswire/ -- Frost & Sullivan's recent analysis of the DNA microarrays market selected Genisphere as the recipient of the 2005 Technology Innovation Award for its success in the microarray market and for developing labeling kits based on the 3DNA dendrimer, an innovative signal amplification technology.
"Microarray technology is utilized widely in important studies such as disease diagnostics, pathway analysis, gene-expression profiling, and gene identification," says Frost & Sullivan industry manager Jessica Shah. "One of the principal causes of variability in microarray experiments is inconsistent incorporation of labeled nucleotides into the cDNA; and by not relying on incorporation of dyes, Genisphere's 3DNA dendrimer technology is unique and it eliminates the variability factor."
Since its inception, this technology has been used in multiple research applications. Researchers are learning the advantages of this novel technology and quickly incorporating it into their research.
Sensitive labeling technology for high quality images and proper analysis of data is crucial to microarray research. In microarray testing, the efficiency of incorporation varies from dye to dye and from sample to sample and Genisphere's 3DNA dendrimer offers increased efficiency and sensitivity.
In addition, 3DNA dendrimers also demonstrate great flexibility and specificity. The architecture of the 3DNA dendrimer has no limitations on the type of specificity or label used. The label may be fluorescent, enzymatic, or radioactive. The application specificity may take the form of a generic sequence, targeted specific sequence, or an antibody.
Furthermore, 3DNA dendrimers are labeled with an average of at least 200 labels. The dendrimer carries these labels with it every time it binds to a complementary molecule, resulting in up to a 200-fold passive enhancement of signal intensity.
"3DNA dendrimers offer a cost-effective solution for researchers due to the high sensitivity enabling them to use less starting material, thereby decreasing costs associated with experimentation," explains Shah. "This technology is currently used by 10 percent of researchers but this number is expected to dramatically increase over the next few years."
Genisphere has vastly contributed to the DNA microarray market through its inventive technology and therefore it is the deserving recipient of the 2005 Frost & Sullivan Technology Innovation Award in the U.S. DNA Microarrays Market.
Each year Frost & Sullivan presents this Award to a company that has demonstrated technological superiority within its industry. The Award recognizes the ability of the company to successfully develop and introduce technology, formulate a well-designed product family, and make significant product performance contributions to the industry.
Genisphere Inc. (Hatfield, PA), a subsidiary of Datascope Corp. (Montvale, N.J.), is a manufacturer of kits and reagents used for the ultra-sensitive detection of nucleic acids and proteins. Genisphere's signal amplification product line is based on its proprietary 3DNA(R) Dendrimers, highly branched DNA molecules capable of delivering hundreds of labels per analyte. 3DNA(R) Dendrimers can be generated in a variety of sizes, deliver a variety of different labels, and target a wide range of biomolecules, making the 3DNA Dendrimers extremely versatile and enabling them to be used in a wide variety of applications. 3DNA Dendrimers have been adapted for use in DNA and protein microarrays, ELISAs, bead-based assays, flow cytometry, in-situ detection of nucleic acids and proteins, and many other applications. Genisphere has also expanded their product line to include proprietary whole transcriptome amplification, through their SenseAmp(TM) product line.
Genisphere distributes products worldwide through direct sales and distributorships. Genisphere has 18 employees who strive to deliver innovative research tools to the research, clinical and diagnostic communities.
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