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Genervon Established That Its Targeted Drug Benefits ALS Disorder Through 8 Pathways and Modulates Over 30 Specific ALS Genes Dynamically


12/13/2012 9:31:28 AM

PASADENA, Calif.--(BUSINESS WIRE)--Genervon scientists have confirmed that the target of GM604 regulates over 4,000 genes. More significantly, it modifies ALS disease progression by modulating at least 30 significant ALS related genes. It does this through at least 8 pathways, potentially more, and up to 22 biological processes. These impressive and broad effects are totally consistent with the role of a master regulator of motoneurons and nervous system in embryonic development. They also offer tremendous potential for broader benefits in fighting ALS and tackling its many disease alterations. GM604 also proved to be quite effective in the disease modification in ALS animal model with mutant SOD1. It led to improved clinical scores in SOD1 mice (p<0.001 for all groups compared to control). Moreover, GM604 delayed the onset of ALS symptoms by 27%, extended life by 30% and delayed the median clinical score deterioration time in ALS mice by 41%. GM604 also provided neuroprotection against soluble inflammatory factors from ALS human patients’ Cerebral Spinal Fluid (CSF) in vitro by 175%.

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