MECHELEN, BELGIUM--(Marketwire - November 26, 2012) - First candidate antibiotic is effective
against all tested MRSA strains
· May offer treatment against multiple drug-resistant
· Proprietary to Galapagos, based on novel target DNA
· Clinical development of first antibiotic initiated
Galapagos NV (Euronext: GLPG) announced
today that it has discovered an entirely new class of antibiotics. The
has selected a candidate drug that shows strong activity against all tested
resistant Staphylococcus aureus, including hospital and community acquired
Bacterial infections that have become resistant to all existing antibiotics
a pressing healthcare problem because treatment options for patients become
limited. MRSA is the best known example: a potentially life-threatening
infection that occurs most frequently among patients in hospitals. The
Galapagos candidate antibiotic shows strong activity against all tested
This newly discovered antibiotic works by inhibiting the target DNA pol III
alpha, an enzyme present in all bacteria and essential for their growth;
target is absent in humans. The novel mode of action - inhibition of DNA
III alpha - may be used to explore a variety of novel antibiotics,
bacteria for which resistance to current antibiotics has emerged.
Using this novel target, Galapagos has selected a first candidate
CAM-1, to enter drug development. CAM-1 was tested against more than
different bacterial strains and effectively killed 100% of all drug
Staph. aureus, including MRSA. CAM-1 shows better efficacy than
antibiotics, as shown by in vivo bacterial infection models. Galapagos
enter the clinic in the first quarter 2014, with a Proof of Concept
thereafter. This novel antibiotic program, including all compounds
MRSA, is fully proprietary to Galapagos.
"Selection of a candidate antibiotic in our MRSA development program
important step toward realizing the full potential of our unique anti-
program," said Dr Piet Wigerinck, Chief Scientific Officer of Galapagos.
antibiotics have a novel mode of action which brings all tested MRSA
a complete halt. Combined with a diagnostic test, these compounds could
real solution to MRSA infections."
Drug resistant infections including MRSA (Methicillin Resistant
aureus) occur most frequently among patients in healthcare settings.
MRSA treatment with antibiotics generates an estimated $4 billion in
revenues. Development of new treatments within existing
antibiotics is complicated by the short timeframe in which resistance
antibiotic emerges. Regulators encourage development of narrow
antibiotics in order to address this dilemma. Current advancements in
diagnostic tests to identify the bacterial strain responsible for the
provide an opportunity for the development of targeted, narrow
Galapagos (Euronext: GLPG; OTC: GLPYY) is a mid-size clinical
biotechnology company specialized in the discovery and development of
molecule and antibody therapies with novel modes-of-action. The
progressing its JAK1 inhibitor GLPG0634, as well as one of the largest
in biotech, with four programs in development and over 30 discovery
The Galapagos Group has over 800 employees and operates facilities
countries, with global headquarters in Mechelen, Belgium. More
This release may contain forward-looking statements, including,
limitation, statements containing the words "believes,"
"expects," "intends," "plans," "seeks," "estimates," "may," "will,"
"stands to," and "continues," as well as similar expressions. Such
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factors which might cause the actual results, financial condition,
or achievements of Galapagos, or industry results, to be materially
from any historic or future results, financial conditions,
achievements expressed or implied by such forward-looking statements.
these uncertainties, the reader is advised not to place any undue
such forward-looking statements. These forward-looking statements speak
of the date of publication of this document. Galapagos expressly
obligation to update any such forward-looking statements in this
reflect any change in its expectations with regard thereto or any
events, conditions or circumstances on which any such statement is based,
required by law or regulation.
"MRSA Drug Futures,"Epsicom, Sept. 2010
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Source: Galapagos NV via Thomson Reuters ONE