Evidence of a Common Genetic Background for Ankylosing Spondylitis and Inflammatory Bowel Disease

Researchers and clinicians have widely noted an intriguing link between some intestinal diseases and some forms of arthritis. In particular, chronic inflammatory bowel disease (IBD) frequently afflicts patients with ankylosing spondylitis (AS), marked by chronic inflammation of the spine and the sacroiliac joints. Separately, both IBD and AS have been shown to run in families. Yet, the specific genetic susceptibility, and whether it is the same for both diseases, remains a mystery.