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Evidence Found for the Genetic Basis of Autism: Models of Autism Show That Gene Copy Number Controls Brain Structure and Behavior, Cold Spring Harbor Laboratory Study



10/6/2011 7:29:10 AM

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. By generating mouse models of autism using a technique known as chromosome engineering, CSHL Professor Alea Mills and colleagues provide the first functional evidence that inheriting fewer copies of these genes leads to features resembling those used to diagnose children with autism.

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