BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Eli Lilly and Company (LLY) Drug Chosen for Alzheimer's Prevention Study


1/22/2013 8:26:33 AM

Researchers have selected Eli Lilly and Co's experimental treatment, solanezumab, for a federally sponsored study of whether Alzheimer's disease can be slowed or prevented in older patients who have not yet developed significant memory problems. The closely watched "A4" prevention study will select 1,000 participants aged 70 to 85 who have varying levels in their brains of amyloid protein - believed to be a main cause of the memory-robbing disease. "This is the first time investigators will test an amyloid-clearing drug in older individuals thought to be in the pre-symptomatic stage of Alzheimer's disease," Brigham and Women's Hospital said on Friday. The affiliate of Harvard Medical School is helping coordinate the three-year study, which could cost up to $100 million. Solanezumab, a monoclonal antibody given by infusion, failed in two earlier Lilly-sponsored trials to slow the progression of the disease in patients who already had mild and moderate symptoms. But when data from the two large Phase III trials was combined and analyzed last summer, cognitive declines were slowed by 34 percent among patients who started out with only mild symptoms. It was the first time any drug ever arrested the progression of Alzheimer's. In the new prevention trial, patients will be selected by using a radioactive Lilly imaging agent called Amyvid (florbetapir) that can detect amyloid plaques in the brain. The agent is approved in the United States and was also approved in Europe this week. Dr. Reisa Sperling, a Harvard neurology professor who will lead the A4 trial, said she and her colleagues are hoping solanezumab will reduce memory decline by 30 percent. That would be similar to the benefit seen among already mildly symptomatic patients in Lilly's earlier pair of large studies.

Read at Reuters
Read at Motley Fool
Read at Seattle Times

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES