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Eleven Biotherapeutics Announces Positive Topline Data on EBI-005, a Novel Topical IL-1 Inhibitor Protein Therapeutic, in Patients With Dry Eye Disease


6/28/2013 9:40:25 AM

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CAMBRIDGE, Mass.--(BUSINESS WIRE)--Eleven Biotherapeutics, a biopharmaceutical company designing and engineering novel and differentiated protein-based biotherapeutics for ocular diseases, announced today positive topline clinical results from a 6-week randomized, double-masked, placebo-controlled Phase 1b/2a study of EBI-005 in patients with dry eye disease (DED). EBI-005 reflects a new approach to the treatment of DED and is the first IL-1 (Interleukin-1) signaling inhibitor designed for topical ocular administration. In the efficacy results from the study, EBI-005 demonstrated statistically significant improvements in signs and symptoms of dry eye disease compared to baseline. In addition, EBI-005 met the predefined efficacy criteria of the study and showed a differential effect between patients who received EBI-005 and those who received only the vehicle control (EBI-005 drug formulation without the active pharmaceutical ingredient). Data from the study showed that EBI-005 was generally safe and well tolerated. The results from the Phase 1b/2a study of EBI-005 confirm similar observations from a recently-published study1 validating the blockade of IL-1 as an efficacious mechanism for treating dry eye disease.

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