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Drug Duo Turns on Cancer-Fighting Gene in Kidney, Breast Cancers, Mayo Clinic Study



8/1/2012 7:20:34 AM

A potentially powerful new approach to treating two lethal metastatic cancers -- triple negative breast cancer and clear cell renal cell carcinoma, the most common form of kidney cancer -- has been discovered by researchers at Mayo Clinic in Florida. In the online issue of Molecular Cancer Therapeutics, they report that two drugs, romidepsin and decitabine, work cooperatively to activate a potent tumor suppressor gene that is silenced in these cancers. Once the gene, secreted frizzled related protein one or sFRP1, went to work after the drugs were used, the laboratory tumor cells stopped growing and died.

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