Dr. Alfred Bach Resigns as CEO of SYGNIS Pharma AG

Heidelberg, 28 October 2010 – SYGNIS Pharma AG (Frankfurt: LIO; ISIN DE0005043509; Prime Standard) announced today that the management contract of Dr. Alfred Bach, which is going to expire at the end of the calendar-year, will not be extended upon Dr. Bach’s request. By mutual consent with the Supervisory Board Dr. Bach will resign as CEO of SYGNIS Pharma AG on the end of 28 October 2010.

The Supervisory Board thanks Dr. Bach for his commitment and efforts during the past years for SYGNIS Pharma AG. Peter Willinger, Chief Financial Officer, and, Dr. Frank Rathgeb, Chief Medical Officer, will jointly lead the Company.

For further information please contact:

Dr. Franz-Werner Haas VP Operations / General Counsel Tel: +49 (0) 6221-454 812 Email: franz-werner.haas@sygnis.de