Data To Be Presented At EASL 2017 Highlighting GENFIT’s Latest Progress In NASH Biomarker Diagnostics, Identifying Novel Compounds With Potent Antifibrotic Properties, And Illustrating The Opportunities In Anti-NASH Drug Combinations
Lille (France), Cambridge (Massachusetts, United States), April 5th, 2017 – GENFIT (Euronext: GNFT - ISIN: FR0004163111), a biopharmaceutical company at the forefront of developing therapeutic and diagnostic solutions in metabolic and inflammatory diseases, that notably affect the liver or the gastrointestinal system, today announced it will present new data at the International Liver Congress 2017[1], which will be held April 19-23 in Amsterdam, The Netherlands. The abstracts are available on the website of the Congress.
A first series of data will underline, via two abstracts, the Company’s latest progress in its non invasive biomarker diagnostics in NASH. Data will also be presented on the discovery of nine miRNAs and their relevance in identifying NASH patients to be treated, and a simple diagnostic score for patients and monitoring of their disease.
The progress presented in a third abstract will support the rationale for the repurposing of nitazoxanide (NTZ), currently prescribed as an antiparisitic, in the treatment of different fibrotic disorders, including liver fibrosis.
A final abstract, presenting data on the therapeutic complementarity of elafibranor and an FXR agonist (exemplified with obeticholic acid), will illustrate the potential for new combination treatments with elafibranor for the best possible care of NASH patients.
The poster presentations:
From Thursday, April 20 to Saturday, April 22, 2017
- “A new non-invasive diagnostic score to monitor change in disease activity and predict fibrosis evolution in patients with NASH”, S. A. Harrison et al. (LBP-534)
- “Next-Generation Sequencing (NGS) of two independent cohorts identifies eleven circulating miRNAs for diagnosis of NASH and fibrosis”, S. Francque et al. (LBP-535)
- “Combination drug therapy allows synergistic therapeutic dose reduction in NASH: a case study of elafibranor (GFT505) and an FXR agonist combination in a model of severe NASH”, V. Ratziu et al. (LBP-542)
Saturday, April 22, 2017
- “Drug repurposing screen identifies novel small molecule compounds with potent antifibrotic properties”, C. Belanger et al. (SAT-345)
GENFIT participation at the International Liver Congress 2017:
GENFIT will host two events:
- Wednesday, April 19 (18:00 – 19:30, Room Elicium 1): Through its endowment fund, The NASH Education Program™, a satellite symposium on “Advances in biomarkers and trial endpoints for NASH and liver fibrosis”, animated by S. A. Harrison, MD (Co-Chair); V. Ratziu, MD, PhD (Co-Chair); R. Loomba, MD, PhD; M. Romero-Gomez, MD, PhD; and Q. M. Anstee, BSc(Hons), MBBS, PhD;
- Friday, April 21: A KOL lunch focused on the NASH space for institutional investors and research analysts, with V. Ratziu, MD, PhD and J-F. Dufour, MD, PhD.
In addition:
- Sophie Mégnien, CMO of GENFIT and member of the Steering Committee of the Liver Forum, will co-chair a working group of the Liver Forum #6, which aims to optimize drug development for the treatment of NASH patients in collaboration with regulatory agencies, learned societies, as well as academic and industry stakeholders;
- GENFIT will be exhibiting at booth #35 throughout the meeting.
For more information please visit the EASL Annual Meeting website: https://ilc-congress.eu/
About elafibranor:
Elafibranor is GENFIT’s lead pipeline product. Elafibranor is an oral once-daily treatment, and a first-in-class drug acting via dual peroxisome proliferator-activated alpha/delta pathways developed to treat, in particular, nonalcoholic steatohepatitis (NASH). Elafibranor is believed to address multiple facets of NASH, including inflammation, insulin sensitivity, lipid/metabolic profile, and liver markers.
About NASH:
“NASH”, or nonalcoholic steatohepatitis, is a liver disease characterized by an accumulation of fat (lipid droplets), along with inflammation and degeneration of hepatocytes. The disease is associated with long term risk of progression to cirrhosis, a state where liver function is diminished, leading to liver insufficiency, and also progression to liver cancer.
About GENFIT:
GENFIT is a biopharmaceutical company focused on the discovery and development of drug candidates in areas of high unmet medical needs corresponding to a lack of suitable treatment and an increasing number of patients worldwide. GENFIT’s R&D efforts are focused on bringing new medicines to market for patients with metabolic, inflammatory, autoimmune and fibrotic diseases, that affect the liver (such as NASH – Nonalcoholic steatohepatitis) and more generally the gastro-intestinal arena. GENFIT’s approach combines novel treatments and biomarkers. Its lead proprietary compound, elafibranor, is currently in a Phase 3 study. With facilities in Lille and Paris, France, and Cambridge, MA (USA), the Company has approximately 130 employees. GENFIT is a public company listed in compartment B of Euronext’s regulated market in Paris (Euronext: GNFT - ISIN: FR0004163111). www.genfit.com
[1] The 52nd Annual Meeting of the European Association for the Study of the Liver (EASL)
A first series of data will underline, via two abstracts, the Company’s latest progress in its non invasive biomarker diagnostics in NASH. Data will also be presented on the discovery of nine miRNAs and their relevance in identifying NASH patients to be treated, and a simple diagnostic score for patients and monitoring of their disease.
The progress presented in a third abstract will support the rationale for the repurposing of nitazoxanide (NTZ), currently prescribed as an antiparisitic, in the treatment of different fibrotic disorders, including liver fibrosis.
A final abstract, presenting data on the therapeutic complementarity of elafibranor and an FXR agonist (exemplified with obeticholic acid), will illustrate the potential for new combination treatments with elafibranor for the best possible care of NASH patients.
The poster presentations:
From Thursday, April 20 to Saturday, April 22, 2017
- “A new non-invasive diagnostic score to monitor change in disease activity and predict fibrosis evolution in patients with NASH”, S. A. Harrison et al. (LBP-534)
- “Next-Generation Sequencing (NGS) of two independent cohorts identifies eleven circulating miRNAs for diagnosis of NASH and fibrosis”, S. Francque et al. (LBP-535)
- “Combination drug therapy allows synergistic therapeutic dose reduction in NASH: a case study of elafibranor (GFT505) and an FXR agonist combination in a model of severe NASH”, V. Ratziu et al. (LBP-542)
Saturday, April 22, 2017
- “Drug repurposing screen identifies novel small molecule compounds with potent antifibrotic properties”, C. Belanger et al. (SAT-345)
GENFIT participation at the International Liver Congress 2017:
GENFIT will host two events:
- Wednesday, April 19 (18:00 – 19:30, Room Elicium 1): Through its endowment fund, The NASH Education Program™, a satellite symposium on “Advances in biomarkers and trial endpoints for NASH and liver fibrosis”, animated by S. A. Harrison, MD (Co-Chair); V. Ratziu, MD, PhD (Co-Chair); R. Loomba, MD, PhD; M. Romero-Gomez, MD, PhD; and Q. M. Anstee, BSc(Hons), MBBS, PhD;
- Friday, April 21: A KOL lunch focused on the NASH space for institutional investors and research analysts, with V. Ratziu, MD, PhD and J-F. Dufour, MD, PhD.
In addition:
- Sophie Mégnien, CMO of GENFIT and member of the Steering Committee of the Liver Forum, will co-chair a working group of the Liver Forum #6, which aims to optimize drug development for the treatment of NASH patients in collaboration with regulatory agencies, learned societies, as well as academic and industry stakeholders;
- GENFIT will be exhibiting at booth #35 throughout the meeting.
For more information please visit the EASL Annual Meeting website: https://ilc-congress.eu/
About elafibranor:
Elafibranor is GENFIT’s lead pipeline product. Elafibranor is an oral once-daily treatment, and a first-in-class drug acting via dual peroxisome proliferator-activated alpha/delta pathways developed to treat, in particular, nonalcoholic steatohepatitis (NASH). Elafibranor is believed to address multiple facets of NASH, including inflammation, insulin sensitivity, lipid/metabolic profile, and liver markers.
About NASH:
“NASH”, or nonalcoholic steatohepatitis, is a liver disease characterized by an accumulation of fat (lipid droplets), along with inflammation and degeneration of hepatocytes. The disease is associated with long term risk of progression to cirrhosis, a state where liver function is diminished, leading to liver insufficiency, and also progression to liver cancer.
About GENFIT:
GENFIT is a biopharmaceutical company focused on the discovery and development of drug candidates in areas of high unmet medical needs corresponding to a lack of suitable treatment and an increasing number of patients worldwide. GENFIT’s R&D efforts are focused on bringing new medicines to market for patients with metabolic, inflammatory, autoimmune and fibrotic diseases, that affect the liver (such as NASH – Nonalcoholic steatohepatitis) and more generally the gastro-intestinal arena. GENFIT’s approach combines novel treatments and biomarkers. Its lead proprietary compound, elafibranor, is currently in a Phase 3 study. With facilities in Lille and Paris, France, and Cambridge, MA (USA), the Company has approximately 130 employees. GENFIT is a public company listed in compartment B of Euronext’s regulated market in Paris (Euronext: GNFT - ISIN: FR0004163111). www.genfit.com
[1] The 52nd Annual Meeting of the European Association for the Study of the Liver (EASL)