BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Data on DermTech International's Non-Invasive Test for Melanoma Are Published in the British Journal of Dermatology


2/8/2011 8:14:58 AM

LA JOLLA, CA--(Marketwire - February 07, 2011) -

DermTech International, Inc, a biotechnology company dedicated to bringing genomic medicine to dermatologists, today announced that the discovery data on its new genomic assay for melanoma have been published in the British Journal of Dermatology. The test is based on the EGIR™ technology (Epidermal Genetic Information Retrieval) that non-invasively collects cells from the skin's surface using a custom adhesive. Details from the paper titled "Non-invasive Genomic Detection of Melanoma" show that the test is 100% sensitive in identifying melanoma.

The EGIR-based technology assessed pigmented skin lesions thought to be suspicious for melanoma and identified all the lesions containing either in situ (early stage) or invasive disease correctly 100% of the time. The test registers 88% specificity (12% false positives). These results are more accurate than any currently available melanoma detection tool. The study was performed at 18 sites across the United States.

"Once it becomes available, this new 'tape stripping' technology will allow us to non-invasively evaluate lesions which might not rise to the level of clinical suspicion that would prompt one to perform a biopsy, but which nonetheless, might harbor melanoma," said Mitchell Kline, MD, Clinical Assistant Professor of Dermatology, New York Presbyterian-Weill Cornell Medical School. "I believe that this genomic-based approach will allow dermatologists to more fully assess patients in advance of a biopsy and the test's very low false positive rate should translate to a reduced number of required excisions. This is a technology I expect will have advantages for patients and the healthcare system."

The paper shows that the EGIR method, which uses adhesive to harvest cells from the skin, identified genes that were differentially expressed in melanomas versus normal skin and nevi. Class prediction modeling identified a 17-gene biomarker that detects both in situ and invasive disease.

As part of the year-long multi-center study, 202 total lesional samples were collected (samples included superficial spreading melanoma, nodular melanoma and lentigo maligna, often misdiagnosed as solar lentigo, a sun spot.)

"Worldwide, the incidence rate of melanoma is climbing faster than any other cancer," said Daniel M. Siegel, MD, incoming President-Elect of the American Academy of Dermatology. "Accurate detection remains the most significant challenge that dermatologists face daily in their practices. Early detection and full excision with proper margins is the only cure for this disease and dermatologists will benefit from tools that help them identify all instances of melanoma. The EGIR technology in development appears to be a major step in this direction."

The current standard of care, an invasive biopsy followed by histopathologic evaluation, typically reveals the presence of melanoma just 3.5-5% of the time. The marked increase in specificity of the genomic test may better identify which of the patient's lesions contain melanoma, effectively helping to direct biopsies.

Many experts believe that, in addition to limiting invasive procedures, the genomic test may be more accurate than today's detection methods.

In one case, as reported in the paper, a lesion that was read to be benign by standard review of histopathology was called positive for melanoma using the biomarker-based test. The patient's tissue was then serial sectioned and re-examined by the pathologists, at which time invasive melanoma was diagnosed.

DermTech is now translating these discovery data onto a quantitative PCR platform. Preliminary results suggest the feasibility of using this 17-gene biomarker in a clinical laboratory setting. Additional sample collection activities are ongoing in the US, Australia and Europe.

"If these findings are confirmed in an expanded clinical validation study, it would establish the EGIR-based assay as a more accurate and cost effective alternative to the currently available tools for melanoma detection," said George Schwartz, CEO, DermTech.

About DermTech International Inc.:

Headquartered in La Jolla, California, DermTech is focused on the development of the company's patented Epidermal Genetic Information Retrieval (EGIR™) technology. The EGIR technology uses a custom adhesive tape to non-invasively and easily collect cells from the stratum corneum, i.e., the upper layer of the skin. Genetic material (RNA) from these cells is then isolated, amplified and analyzed using molecular biology tools to determine genetic profiles to be used for a range of applications including: the non-invasive, early detection of disease, pharmaceutical R&D and theranostics. DermTech is actively pursuing research using the EGIR technology in the areas of melanoma, prostate cancer and a number of skin conditions. For additional information visit: www.dermtech.com.

About Melanoma:
Since 1930, there has been a 2000 times increase in the lifetime risk of developing melanoma. By 2010, current estimates indicate that 1 out of 50 people will be diagnosed with melanoma during their lifetime. (1) Melanoma is the most common cancer in women aged 25-29. 5% to 10% of cases of cutaneous melanoma are the result of hereditary genetics in first-degree relatives.(2) Unlike most other cancers, melanoma only infrequently responds to treatment and those that are available are highly toxic and impact quality of life.(3) If melanoma is treated before it spreads, it is 99% curable.(4) The ten-year survival rate for melanoma patients whose disease is detected and treated at the earliest stages is 95-99% but drops to less than 5% for a Stage 4 melanoma (invasive)(5).

(1) CA Cancer J Clin 2008

(2) Karolinska Institute, Aug 2008

(3) NCI Melanoma Treatment Options

(4) AAD Fact Sheet 2007

(5) American Joint Committee on Cancer - AJCC.

For broadcast media go to: www.newsinfusion.com/events/dermtech


Contacts:
DermTech
George Schwartz
CEO
858.450.4222

Jennifer Larson
415.725.2017
jlarson@dermtech.com

Digg this    Bookmark with del.icio.us    Add to Newsvine

Technorati:



Read at BioSpace.com

   
Melanoma

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES