Dartmouth Medical School Researchers Identify Enzymatic Activity of Neurological Disease Gene

Opening a window to understand the molecular basis of a hereditary ataxia, Dartmouth Medical School researchers have identified an enzyme activity that is inactivated in all reported mutant forms of a disease protein. The discovery may lead to therapies to treat the neurological disease. The study appears in the June 3, 2005 issue of the Journal of Biological Chemistry (JBC) as Paper of the Week, an honor conferred on approximately 1% of JBC's 6600 annual publications.

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