COPENHAGEN, Denmark, Oct. 12, 2012 /PRNewswire/ A pioneer in image guided radiotherapy (IGRT) in Denmark, Copenhagen University Hospital (CUH, Herlev) was the first in the country to incorporate MRI in radiotherapy imaging simulation to guide radiotherapy of lung cancer patients. Continuing its tradition of IGRT firsts, CUH is the first hospital in Scandinavia to acquire Elekta's Clarity® soft tissue visualization system with Autoscan.
CUH medical physicist Mariwan Baker, M.Sc., will use Clarity to further quantify the value of non-invasive, non-ionizing 3D ultrasound in increasing radiation therapy precision.
"3D ultrasound is non-invasive and cost effective, and provides soft tissue information that is complementary to CT images," Baker observes. "Unlike CT, however, Clarity will enable daily imaging prior to treatment, which will help our oncologists account for interfraction variations in the target position and more precisely target the tumor by the prescribed planned dose."
The first projects will involve Clarity studies of gynecological and prostate targets.
Baker's research, the subject of his Ph.D. thesis, focuses on the potential to use Clarity for addressing the magnitude of uterus displacement in gynecological patients on a daily basis. Furthermore, the research encompasses the implementation of Clarity for 4D monitoring to evaluate intrafraction changes in prostate position. Baker will first assess the extent of prostate shifts, a well-known phenomenon in radiotherapy, and will build on that knowledge by examining dosimetry variations caused by intrafraction prostate motion.
"It's not simply evaluating the magnitude of the displacement," he explains. "We have to get an idea about how much this displacement is influencing the dose distribution around the tumor, and of course, around the organs-at-risk."
To accomplish this, Baker will be using Clarity 3D with Autoscan along with a 4D phantom that will be developed by CUH for ultrasound tracking with embedded real-time detectors.
"The phantom will simulate the prostate, enabling us to compare the dose recorded by dosimeters with and without compensating for motion," he notes.
Breast imaging with Clarity
In addition to prostate and gynecological Clarity research, Baker mentioned the potential of an initial study on imaging the tumor cavity movement in post-operative breast cancer patients.
"A patient being treated post-operatively can have a least 25 fractions, so shrinkage of the cavity is an issue," he says. "Pre-treatment imaging with Clarity can address that."
Individuals with breast cancer represent 30 percent of CUH's radiotherapy patient volume.
Baker predicts that clinical use of Clarity at CUH will begin in early 2013.
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Elekta is a human care company pioneering significant innovations and clinical solutions for treating cancer and brain disorders. The company develops sophisticated, state-of-the-art tools and treatment planning systems for radiation therapy, radiosurgery and brachytherapy, as well as workflow enhancing software systems across the spectrum of cancer care. Stretching the boundaries of science and technology, providing intelligent and resource-efficient solutions that offer confidence to both healthcare providers and patients, Elekta aims to improve, prolong and even save patient lives.
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