Cornerstone Pharmaceuticals, Inc. Partners With Wake Forest University On Clinical Trial Of CPI-613 For Hematologic Malignancies

CRANBURY, N.J., April 19 /PRNewswire/ -- Cornerstone Pharmaceuticals, Inc. (http://www.cornerstonepharma.com), a private pharmaceutical company, with a singular focus on cancer metabolism, has announced today that U.S. regulatory clearance has been obtained for the initiation of a physician-sponsored, Phase I human clinical trial of Cornerstone's first-in-class anticancer agent, CPI-613.

"We are very grateful to be expanding our previously established relationship with Wake Forest University and Dr. Pardee's research laboratory, which involves the evaluation of CPI-613 in a mouse model of acute myeloid leukemia (AML), considered to be predictive of responsiveness to drug treatment in humans, to the clinical evaluation of CPI-613 in patients with advanced leukemias and lymphomas," remarked Dr. Robert Shorr, Chief Executive Officer for Cornerstone Pharmaceuticals.

Chemotherapy resistance is a major cause of death in patients with advanced hematologic malignancies. The proposed novel mechanism of action, non-cross resistance with chemotherapeutic agents currently used in the clinic, and lack of CPI-613-related myelosuppression in humans to date, make CPI-613 a suitable candidate for clinical evaluation in these types of cancers.

About Dr. Timothy S. Pardee

Dr. Timothy S. Pardee is an Assistant Professor in the Section on Hematology and Oncology in the Department of Internal Medicine at Wake Forest University Baptist Medical Center, an academic health system comprised of North Carolina Baptist Hospital, Brenner Children's Hospital, Wake Forest University Physicians, and Wake Forest University Health Sciences, which operates the university's School of Medicine. The system includes 1,069 acute care and rehabilitation beds and has been ranked as one of "America's Best Hospitals" by U.S. News & World Report since 1993. Dr. Pardee was a Postdoctoral Fellow at the Dr. Scott Lowe Laboratory at Cold Spring Harbor Laboratories, NY. Prior to that, he was a Hematology/Oncology Fellow at Stony Brook University in New York following his Internal Medicine Residency at Massachusetts General Hospital. Dr. Pardee received his MD and PhD from the University of Buffalo. Dr. Pardee is a recipient of both the Stony Brook Clinical Scholar Award and the Ambassador Felix Schnyder Memorial Fund Grant from the Lauri Strauss Leukemia Foundation.

Cornerstone's AEMD technology platform was established on cancer metabolism research performed in the laboratories of Paul M. Bingham, Ph.D. and Zuzana Zachar, Ph.D., at the State University of New York at Stony Brook, Stony Brook, NY.

Cornerstone Pharmaceuticals, Inc.


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