Cordis Corporation: New Study Shows Excellent Outcomes for CYPHER® Sirolimus-Eluting Coronary Stent in Treatment of Completely Blocked Coronary Arteries

WASHINGTON--(BUSINESS WIRE)--Implantation of the CYPHER® Sirolimus-eluting Coronary Stent to treat completely blocked coronary arteries led to substantial reductions in recurrent blockage and the need for repeat treatment compared to bare metal stents in a study presented today at the Transcatheter Cardiovascular Therapeutics 2007 meeting (TCT 2007). Researchers reported that the Approaches to Chronic Occlusions with Sirolimus-eluting Stents (ACROSS-CYPHER) study met its primary endpoint, which was the assessment of angiographic restenosis at six-month follow-up. Among 200 patients treated with the CYPHER® Stent following successful reopening of a completely blocked coronary artery (chronic total occlusion), the likelihood of renarrowing of the treated segment (angiographic restenosis) was reduced by 65.6 percent compared with a pre-specified cohort of patients treated with a bare metal stent in the earlier Total Occlusion Study of Canada (TOSCA-1) trial. In the entire segment treated with balloon angioplasty and stents, the restenosis rate for the CYPHER® Stent was 19.0 percent while the restenosis rate for the bare metal stent was 55.2 percent. Following risk adjustment, these differences translated into an 84 percent reduction in the primary endpoint (p<0.0001). Further, restenosis occurring only within the CYPHER® Stent-treated area was 7.5 percent.