Cellular Dynamics Announces Launch Of World’s Largest Public Stem Cell Bank And The Availability Of The First 300 Ipsc Lines

MADISON, Wis.--(BUSINESS WIRE)--Cellular Dynamics International, Inc. (CDI), a FUJIFILM company, today announced the launch of the world’s largest publicly available stem cell bank, the California Institute for Regenerative Medicine (CIRM) hPSC Repository, and the availability of the first 300 induced pluripotent stem cell (iPSC) lines in September. These high quality, disease-specific iPSC resources are now accessible to academic and industry researchers for disease modeling, target discovery and drug discovery.

“Coriell Institute is a leader in managing large and complex biospecimen collections and distributing samples and data worldwide to promote research. We are very pleased to be part of this CIRM initiative and advance stem cell research for several devastating yet common diseases.”

Key Points

• In 2013, CIRM awarded CDI $16 million to create induced pluripotent stem cell (iPSC) lines for each of 3,000 healthy and diseased volunteer donors across 11 common diseases and disorders to be made available through the CIRM hPSC Repository.
• In September the CIRM hPSC Repository will launch the first 300 iPSC lines, which include cells from healthy donors and donors suffering from non-alcoholic steatohepatitis (NASH), dilated cardiomyopathy, diseases of the eye and autism. The number of available cell lines is expected to increase to 750 by February 2016.
• iPSC lines can be created from any individual, and thus provide a powerful tool for understanding disease as well as studying genetic variation between individuals. Patient samples are collected primarily from standard doctor’s office blood draws.
• The iPSC lines are accompanied by detailed demographic and clinical data and were made from tissue samples collected from living donors.
• iPSCs have the potential to be differentiated into any cell type in the human body, and CDI already routinely manufactures 12 iPSC-derived cell types, including heart, neural, liver and endothelial cells, in high quantity, quality, and purity. Through CDI’s MyCell® Product portfolio, researchers can order iPSC line(s) of interest and have them differentiated into the cell type of choice.
• Researchers can obtain undifferentiated iPSC lines through the Coriell Institute for Medical Research.

Quotes

Kaz Hirao, CDI Chairman and CEO, said, “iPSCs are proving to be powerful tools for disease modeling, drug discovery and the development of cell therapies, capturing human disease and individual genetic variability in ways that are not possible with other cellular models. We’ve seen a dramatic increase in the availability of iPSC lines. We’re pleased to be the vendor of choice for creating high quality iPSC lines and enabling scientists from academia and industry to better understand and help develop treatments for major diseases. The lines available from the CIRM stem cell bank directly complement CDI’s ability to provide differentiated cells corresponding to each of these iPSC lines, which will allow researchers to model the diseases represented, better understand disease progression, perform more targeted drug discovery, and ultimately lead to better treatments.”

Jonathan Thomas, Ph.D., J.D., CIRM Chairman, said, “We believe the bank will be an extraordinarily important resource in helping advance the use of stem cell tools for the study of diseases and finding new ways to treat them. While many stem cell efforts in the past have provided badly needed new tools for studying rare genetic diseases, this bank represents common diseases that afflict many Californians. Stem cell technology offers a critical new approach toward developing new treatments and cures for those diseases as well.”

Michael Christman, Ph.D., president and CEO of Coriell said, “Coriell Institute is a leader in managing large and complex biospecimen collections and distributing samples and data worldwide to promote research. We are very pleased to be part of this CIRM initiative and advance stem cell research for several devastating yet common diseases.”

About Fujifilm

Cellular Dynamics International (CDI), a FUJIFILM company, is a leading developer and manufacturer of human cells used in drug discovery, toxicity testing, stem cell banking, and cell therapy development. The Company partners with innovators from around the world to combine biologically relevant human cells with the newest technologies to drive advancements in medicine and healthier living. CDI’s technology offers the potential to create induced pluripotent stem cells (iPSCs) from anyone, starting with a standard blood draw, and followed by the powerful capability to develop into virtually any cell type in the human body. Our proprietary manufacturing system produces billions of cells daily, resulting in inventoried iCell® products and donor-specific MyCell® Products in the quantity, quality, purity, and reproducibility required for drug and cell therapy development. Founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research, Cellular Dynamics is based in Madison, Wisconsin, with a second facility in Novato, California. For more information, please visit www.cellulardynamics.com, and follow us on Twitter @CellDynamics.

FUJIFILM Holdings Corporation, Tokyo, Japan brings continuous innovation and leading-edge products to a broad spectrum of industries, including: healthcare, with medical systems, pharmaceuticals and cosmetics; graphic systems; highly functional materials, such as flat panel display materials; optical devices, such as broadcast and cinema lenses; digital imaging; and document products. These are based on a vast portfolio of chemical, mechanical, optical, electronic, software and production technologies. In the year ended March 31, 2015, the company had global revenues of $20.8 billion, at an exchange rate of 120 yen to the dollar. Fujifilm is committed to environmental stewardship and good corporate citizenship. For more information, please visit: www.fujifilmholdings.com.

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