Calistoga Pharmaceuticals Presents Preclinical and Clinical Data Supporting Benefit of First in Class, Novel Mechanism of CAL-101, an Oral Delta Isoform-Selective PI3 Kinase Inhibitor
SEATTLE--(BUSINESS WIRE)--Calistoga Pharmaceuticals, Inc., the leader in the development of isoform-selective phosphatidylinositol 3 kinase (PI3K) inhibitors for the treatment of cancer and inflammatory diseases, today presented preclinical and clinical data on CAL-101, the Company’s oral, delta selective PI3K inhibitor at the 15th Congress of the European Hematology Association in Barcelona, Spain. Results from the interim assessment of the ongoing Phase 1 clinical trial demonstrate clinical benefit in patients with relapsed or refractory indolent non-Hodgkin’s lymphoma (NHL), mantle cell lymphoma (MCL), and chronic lymphocytic leukemia (CLL). Preclinical results assessing selected chemokines in plasma and circulating CLL cells from patients in the Phase 1 clinical trial support that CAL-101 inhibits chemokine signaling and production from CLL cells and the microenvironment. These results elucidate the novel biological effects of CAL-101 and are consistent with the single agent activity observed in Phase 1 evaluation, particularly the biologic activity observed in nearly all CLL patients.