Bristol-Myers Squibb Company, AstraZeneca PLC Diabetes Pill Faces Safety Hurdles

Bristol-Myers Squibb Co. (BMY) and AstraZeneca Plc. (AZN)’s new diabetes pill will probably face increased scrutiny from regulators and doctors after two rivals were tied to cancer and heart risks. The drug, dapagliflozin, works differently than Takeda Pharmaceutical Co.’s Actos, linked to cancer last week, and GlaxoSmithKline Plc (GSK)’s Avandia, tied to heart risks in 2007. While those drugs adjust the hormone that regulates sugar, the new pill helps patients excrete sugar through their urine. “Increasingly, people are on the lookout for problems with these drugs,” said Laurence Kennedy, chairman of Cleveland Clinic’s department of endocrinology, diabetes and metabolism, in a telephone interview. “There will always be a market for finding newer and different ways to help control blood sugar, but the newest ways will be under increasing scrutiny.”

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