Brain Prosthesis Passes Live Tissue Test

The world’s first brain prosthesis has passed the first stages of live testing. The microchip, designed to model a part of the brain called the hippocampus, has been used successfully to replace a neural circuit in slices of rat brain tissue kept alive in a dish. The prosthesis will soon be ready for testing in animals. The device could ultimately be used to replace damaged brain tissue which may have been destroyed in an accident, during a stroke, or by neurodegenerative conditions such as Alzheimer’s disease. It is the first attempt to replace central brain regions dealing with cognitive functions such as learning or speech. To achieve their result, Theodore Berger and his colleagues at the University of Southern California in Los Angeles, US, had to develop a system that would “read” real neural signals from healthy tissue, process them just as the lost brain tissue should, and pass on the resulting signals to the next brain area. The brain region they are trying to replace is the hippocampus, which is vital for forming memories. The hippocampus has a well-understood three-part circuit. It also has a regular repeating structure, so elements of all three parts of the hippocampal circuit can be kept in a fully functional state, even in small slices in a culture dish.

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