Bone Therapeutics Release: €1 Million Funding Secured From The Walloon Region To Investigate These Innovative Products For The Treatment Of Large Bone Defects
Gosselies, Belgium, 5 January 2015 - BONE THERAPEUTICS, the regenerative therapy company addressing unmet medical needs in the fields of fracture repair and bone fracture prevention, today announces that it has begun a new research project to investigate novel combined osteoblastic cell-matrix products for the treatment of large bone defects. The government of the Walloon Region has granted the Company €1 million of non-dilutive funding, in the form of recoverable cash advances, to finance this project.
In the project entitled “MXB Bioprinting”, Bone Therapeutics will combine its allogeneic[1] bone-forming (osteoblastic) cells within a 3-D bioprinted scaffold to treat large bone defects2 resulting from trauma, bone disease or surgical procedures such as bone metastasis resection. This innovative approach represents a compelling alternative to bone autograft, the current standard-of-care for large bone defects, which is associated with significant morbidities.
The cell-matrix scaffold will be tailored to the size and form of the bone defect and will be designed to mimic the natural bone in terms of shape, structure and biomechanical properties. Once implanted, the 3-D patient-tailored matrix is intended to be progressively replaced by natural bone tissue, produced by the off-the-shelf osteoblastic cells as well as by the ones from the patient that will have been recruited at the site. Furthermore, as achieving adequate vascularization can be problematic due to the size of these defects, the product is designed to mitigate against this risk. The cells in the matrix will also be designed to stimulate the formation of new blood vessels by releasing factors that recruit endothelial cells (which are involved in the formation of blood vessels) to the defect site.
Enrico Bastianelli, Chief Executive Officer of Bone Therapeutics commented: “This novel approach utilising our allogeneic bone-forming cells within a precisely patient tailored 3-D bioprinted structure could herald a new and highly effective treatment for large bone defects and success in a field where regenerative medicine was thought to be untenable. We are grateful to the Walloon region in supporting this important project.”
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About Bone Therapeutics
Bone Therapeutics is a leading biotechnology company specializing in the development of innovative regenerative therapies for the repair and prevention of bone fractures. The current standard of care in this field involves major surgeries and long recovery periods. To overcome these problems, Bone Therapeutics is developing a range of innovative products containing regenerative osteoblastic/bone-forming cells, administrable via a minimally invasive percutaneous technique; a unique proposition in the market.
PREOB®, Bone Therapeutics’ autologous cell product, is currently in pivotal Phase III clinical studies for two indications: osteonecrosis and non-union fractures, and in Phase II for severe osteoporosis. ALLOB®, its allogeneic cell product, is in Phase II for the treatment of delayed-union fractures and lumbar fusion for degenerative disease of the spine. The Company also runs preclinical research programs and develops novel product candidates.
Founded in 2006, Bone Therapeutics is headquartered in Gosselies (South of Brussels, Belgium). Bone Therapeutics’ regenerative products are manufactured to the highest GMP standards and are protected by a rich IP estate covering 9 patent families. Further information is available at www.bonetherapeutics.com
Bone Therapeutics SA
Tel: +32 (0)2 529 59 90
Enrico Bastianelli, Chief Executive Officer
Wim Goemaere, Chief Financial Officer
info@bonetherapeutics.com
Consilium Strategic Communications
Amber Bielecka, Mary-Jane
Elliott, Jessica Hodgson, Lindsey Neville
Tel: +44 (0) 20 3 709 5700
bonetherapeutics@consiliumcomms.com
Help employers find you! Check out all the jobs and post your resume.
In the project entitled “MXB Bioprinting”, Bone Therapeutics will combine its allogeneic[1] bone-forming (osteoblastic) cells within a 3-D bioprinted scaffold to treat large bone defects2 resulting from trauma, bone disease or surgical procedures such as bone metastasis resection. This innovative approach represents a compelling alternative to bone autograft, the current standard-of-care for large bone defects, which is associated with significant morbidities.
The cell-matrix scaffold will be tailored to the size and form of the bone defect and will be designed to mimic the natural bone in terms of shape, structure and biomechanical properties. Once implanted, the 3-D patient-tailored matrix is intended to be progressively replaced by natural bone tissue, produced by the off-the-shelf osteoblastic cells as well as by the ones from the patient that will have been recruited at the site. Furthermore, as achieving adequate vascularization can be problematic due to the size of these defects, the product is designed to mitigate against this risk. The cells in the matrix will also be designed to stimulate the formation of new blood vessels by releasing factors that recruit endothelial cells (which are involved in the formation of blood vessels) to the defect site.
Enrico Bastianelli, Chief Executive Officer of Bone Therapeutics commented: “This novel approach utilising our allogeneic bone-forming cells within a precisely patient tailored 3-D bioprinted structure could herald a new and highly effective treatment for large bone defects and success in a field where regenerative medicine was thought to be untenable. We are grateful to the Walloon region in supporting this important project.”
-Ends-
About Bone Therapeutics
Bone Therapeutics is a leading biotechnology company specializing in the development of innovative regenerative therapies for the repair and prevention of bone fractures. The current standard of care in this field involves major surgeries and long recovery periods. To overcome these problems, Bone Therapeutics is developing a range of innovative products containing regenerative osteoblastic/bone-forming cells, administrable via a minimally invasive percutaneous technique; a unique proposition in the market.
PREOB®, Bone Therapeutics’ autologous cell product, is currently in pivotal Phase III clinical studies for two indications: osteonecrosis and non-union fractures, and in Phase II for severe osteoporosis. ALLOB®, its allogeneic cell product, is in Phase II for the treatment of delayed-union fractures and lumbar fusion for degenerative disease of the spine. The Company also runs preclinical research programs and develops novel product candidates.
Founded in 2006, Bone Therapeutics is headquartered in Gosselies (South of Brussels, Belgium). Bone Therapeutics’ regenerative products are manufactured to the highest GMP standards and are protected by a rich IP estate covering 9 patent families. Further information is available at www.bonetherapeutics.com
Bone Therapeutics SA
Tel: +32 (0)2 529 59 90
Enrico Bastianelli, Chief Executive Officer
Wim Goemaere, Chief Financial Officer
info@bonetherapeutics.com
Consilium Strategic Communications
Amber Bielecka, Mary-Jane
Elliott, Jessica Hodgson, Lindsey Neville
Tel: +44 (0) 20 3 709 5700
bonetherapeutics@consiliumcomms.com
Help employers find you! Check out all the jobs and post your resume.