PRLog (Press Release) - Mar. 26, 2013 - MONMOUTH JUNCTION, N.J. -- Biotech Support Group LLC, reports on a new technical poster which describes a new enrichment product – PROfessor™, for functional and chemical proteomic applications. Entitled “New New Chemical Proteomic Methods to Access Drug-protein Interactions”, it was presented at the US HUPO Conference in Baltimore, MD, March 10-11, 2013. The poster report describes two important features of the product: 1) a new way to compress protein concentrations in complex samples thereby enriching the low abundance content, and 2) a method called compound-centric displacement proteomics (CCDP) to enrich for the complement interactome of a small molecule or drug. The latter method does not require the surface immobilization of the compound which can distort the orientation and lead to misleading results.
“By taking a composite mix of 6 mixed mode surface chemistries, we are able to achieve protein compression when protein loads exceed the binding capacity of the product. Furthermore, the same phenomena – weak binding energy of the proteins to the surface which allows us to achieve compression, also allows subproteomes, the interactomes if you will, to be displaced by the conformational changes associated with drug binding” states Swapan Roy, Ph.D, President & Founder of Biotech Support Group. “With this product, which can be applied universally towards any sample type and any small molecule compound, we envision new chemical proteomic strategies for annotating and correlating drugs to tissue specific isoforms, accessing promiscuity, elucidating mechanism of action, and identifying biomarkers for personalized medicine.”
The poster can be viewed at http://biotechsupportgroup.com/sites/default/files/Biotec...
About Biotech Support Group LLC
Biotech Support Group LLC is a leading developer of proteomic and genomic sample preparation and enrichment products. Its principal products include: AlbuVoid™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ & ProPrep™ for nucleic acid isolation. For more information, go to www.biotechsupportgroup.com
Dr. Swapan Roy
Biotech Support Group