PRLog (Press Release) - Apr. 2, 2013 - MONMOUTH JUNCTION, N.J. -- MONMOUTH JUNCTION, N.J. -- Scale up of lipid removal treatments on samples of ascites, serum, cell & tissue culture, bile and organ homogenates using centrifugation or ultrafiltration is challenging. Sources of lipids in cells are phospholipids, glycolipids, cholesterol and plasma lipids. Cleanascite™ removes lipids and preserves the protein structure and biological activity. Cleanascite™ selectively removes lipids, cell debris, lipoproteins, floating fats, impurities from cohn paste, egg yolk and biological samples for pretreatment prior to purification. The reagent is a solid-phase, non-ionic adsorbent supplied as a suspension in saline, ready for use. Simply add, centrifuge and/or filter. The clarified supernatant is ready for subsequent downstream processing or analysis. Cleanascite™ extends the life of membrane and chromatographic columns. Enrichment, sample preparation and proteomic processes are more effective subsequent to using Cleanascite™. Cleanascite™ complements adsorptive matrices which are used for protein delipidation treatments. Moreover delipidation treatments are effective in protein recovery and optimizes assays of chromatography techniques for purification of biopharmaceutical proteins. Cleanascite™ is ideal for high throughput, high yield therapeutic protein clarification as it removes lipids. Cleanascite™ clarifies lipids from recombinant and natural proteins in transgenic milk allowing for downstream processes which isolate proteins such as IgG and recombinant human protein C from human plasma.
Characteristics of Cleanascite™ Lipid Removal Reagent and Clarification
Extends the life of membrane and chromatographic columns.
Ideal for clarifying ascites, serum, cell & tissue culture, bile and organ homogenates
A high binding capacity for lipids with minimal cross-reactivity with proteins
Helps purify antibodies, recombinant proteins, nucleic acids, proteoglycans
Clarifies saliva and fecal components
Very low protein binding
For more information on Cleanascite™ and references please visit
Cleanascite™ Lipid Removal Reagent and Clarification
About Biotech Support Group LLC
Biotech Support Group LLC is a leading developer of proteomic and genomic sample preparation and enrichment products. Its principal products include: AlbuVoid™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ & ProPrep™ for nucleic acid isolation. For more information, go to www.biotechsupportgroup.com.
Biotech Support Group