Biotech Holdings Ltd. Working With TSX Venture Exchange Re: Independent Directors

VANCOUVER, Dec. 23 /PRNewswire-FirstCall/ - Biotech Holdings Ltd.(the "Company") announces that on December 6th, 2005, the TSX Venture Exchange (the "Exchange") halted trading in the common shares of the Company pending the appointment of two independent directors to the Company's board of directors who are satisfactory to the Exchange, including possessing the requisite degree of positive public company experience. Currently, the Exchange is reviewing proposed directors identified by the Company to determine suitability. In addition, the Company announces the resignation of Dr. Geoff Herring to provide room on the board of directors for the new appointments, when made, as well as to allow Dr. Herring to pursue his other interests. Dr. Herring will continue to be a consultant to the Company.

Currently, the Company is working with the Exchange to satisfy the Exchange requirements for new board members and is in the process of identifying candidates to propose to the Exchange.

Biotech Holdings Ltd. is based in Richmond, British Columbia. Biotech Holdings trades on the Over the Counter Bulletin Board in the United States , on the TSX Venture Exchange and on the Frankfurt Exchange (925970.F).

For inquiries, contact Austin Rand at Biotech Holdings Ltd., 1 888 216 1111 (toll-free), 8 a.m. to 5 p.m. Pacific time, or by e-mail at biotech@direct.ca. For background information and current stock quotations, please visit Biotech's website at www.biotechltd.com.

This release has been approved by the Board of Directors of Biotech Holdings.

The TSX Venture Exchange has not reviewed and does not accept

responsibility for the adequacy or accuracy of this release.

Any statements made in this release that are not based on historical fact are forward-looking statements. Any forward-looking statements made in this release represent management's best judgement as to what may occur in the future. However, actual outcome and results are not guaranteed and are subject to certain risks, uncertainties and assumptions and may differ materially from what is expressed.

CONTACT: For inquiries, contact Austin Rand at Biotech Holdings Ltd.,1-888-216-1111 (toll-free), 8 a.m. to 5 p.m. Pacific time, or by e-mail atbiotech@direct.ca. For background information and current stock quotations,please visit Biotech's website at www.biotechltd.com.; To request a freecopy of this organization's annual report, please go tohttp://www.newswire.ca and click on Tools for Investors.