Melbourne, 8 January 2013: Infectious disease therapy development company BioDiem Ltd (ASX:BDM) says a
study examining the effect of its novel anti-microbial BDM-I against the parasite which causes schistosomiasis
(bilharzia), a major disease of the developing world, is progressing to the next stage due to early positive results. This
work will assist the commercial development of BDM-I for the treatment of infectious diseases.
The initial in vitro research led by Professor Don McManus, based at the Queensland Institute of Medical Research
(QIMR), found BDM-I could kill a Philippines-based strain (Schistosoma japonicum) of a parasitic worm.
The Company today said Prof McManus and QIMR would proceed with a broader proof-of-concept investigation
looking at multiple parasite strains and at different lifecycle stages. If successful, BioDiem will then continue into an
efficacy study in schistosoma-infected mice.
“Schistosomiasis is a major cause of liver, bladder and kidney disease and death across the developing world and it
is recognised as a Neglected Tropical Disease,” said BioDiem Chief Executive Officer Julie Phillips.
“This next phase of research, while early days, may point us to a new way to treat the many tens of millions of people
now living with this disease. It may also guide us as to how to prevent the disease progressing to this stage.”
People contract schistosomiasis, which has a health burden second only to malaria among parasitic diseases, via
contact with unsanitary water. The larval form of parasitic worms found in fresh-water snails can penetrate human
skin, and go on to live within the body resulting in progressive organ damage.
“It is our hope BDM-I could underpin a new treatment option for world health agencies as they grapple with this
parasite in the many countries where sanitary water, for drinking and bathing, cannot be taken for granted,” Ms
Phillips also said.
About BioDiem Ltd
BioDiem (ASX: BDM) is an ASX-listed company based in Melbourne with an international focus on discovering,
developing and commercialising world-class research and technology targeting infectious diseases and related
cancers. BioDiem’s core technologies include the Live Attenuated Influenza Virus (LAIV), the BDM-I antimicrobial
compound and the SAVINE vaccine technology platform. BioDiem has also in-licensed vaccine technologies from
Australian National University and the University of Canberra with initial target indications of dengue fever and
ABN 20 096 845 993
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470 Collins Street,
Melbourne, Victoria, 3000
Phone: +61 3 9613 4100
Fresh-water snails carry the schistosoma worms, otherwise known as blood flukes, which shed their larval form into
the water. This larva can penetrate human skin where the worms go on to live in blood vessels and can cause
progressive organ damage and cancer. Liver, bladder and kidney disease is a common health impact. The World
Health Organization estimates more than 230 million people require treatment for schistosomiasis yearly. The number
of people treated with conventional therapy for schistosomiasis rose from 12.4 million in 2006 to 33.5 million in 2010.
BDM-I is a synthetic compound targeting the treatment of serious human infections. BDM-I is in the preclinical stage
with outlicensing as the intended outcome. BDM-I is active against a range of pathogenic micro-organisms including
gram-positive and gram-negative bacteria, fungi and protozoa. Key patents have been granted in Europe, Japan and
the US around BDM-I’s antimicrobial activity, including activity against Plasmodium falciparum, responsible for
causing the most commonly severe form of malaria, and Trichomonas vaginalis, the protozoan responsible for
causing a common sexually transmitted disease named trichomoniasis.
For additional information, please visit www.biodiem.com
Julie Phillips, Chief Executive Officer Shevaun Cooper
BioDiem Ltd Buchan Consulting
Phone +61 3 9613 4100 Phone +61 3 8866 1218 / +61 421 760 775
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