Beckman Coulter, Inc. Release: Anti-Osteoclast-Associated Receptor (OSCAR)-PE RUO Monoclonal Antibody Expands Study Of Dendritic Cell Functions

Fullerton, Calif. (September 25, 2006) – Beckman Coulter, Inc. introduces the IOTest® Anti-OSCAR-PE conjugated monoclonal antibody. In humans, the OSCAR antigen is expressed on osteoclasts, which are involved in bone development and remodeling, and on myeloid dendritic cells, among others. OSCAR is the first FcR?-associated molecule described on human myeloid dendritic cells. It is an activating molecule involved in antigen capture and presentation that may modulate the response of both innate and adaptive immunity. With the new Anti-OSCAR-PE Monoclonal Antibody, researchers can tag a new antigen that is thought to be implicated in the tolerogenic function of dendritic cells.

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