News | News By Subject | News by Disease News By Date | Search News
Get Our FREE
Industry eNewsletter

Astex Therapeutics Announces Commencement of Phase I Study for AZD5363 in Anti-Cancer Collaboration with AstraZeneca PLC (AZN)

4/12/2011 10:33:16 AM

Cambridge, UK, 12th April 2011. Astex Therapeutics, the UK-based biotechnology company developing targeted therapies for oncology, confirms the commencement of a Phase I study for AZD5363, a Protein Kinase B (PKB, also known as Akt) inhibitor. AZD5363 is a clinical candidate selected in January 2010 by AstraZeneca subsequent to its collaborative programme with Astex. The collaborative programme originated from an earlier Astex collaboration with The Institute of Cancer Research (ICR) and Cancer Research Technology Limited (CRT) which began in 2003.

AZD5363 is an orally active selective inhibitor of PKB/Akt, a key enzyme in the PI3K/PKB/mTOR tumour cell survival pathway, and dysregulation of this pathway leads to tumour resistance to a number of important anti-cancer drugs. Inhibition of PKB/Akt has potential in the treatment of a broad range of cancer types.

The Phase I study, being conducted at multiple centres in Europe, is designed to investigate the safety, tolerability and preliminary anti-cancer activity of AZD5363 in patients with advanced solid tumours, and to identify a dose and schedule that can be used in Phase II trials1.

Commenting on the announcement, Harren Jhoti, Chief Executive Officer of Astex, said: “We are delighted that the long-standing collaboration between AstraZeneca, Astex, The Institute of Cancer Research and Cancer Research Technology, has delivered this exciting new compound. We anticipate that targeted agents like AZD5363, when fully researched, will provide new therapeutic options to patients with cancers of high unmet medical need. This is the second of our partnered programmes to commence human clinical trials, and is a further example of the productivity of our drug discovery partnerships with major pharmaceutical companies.”

1Assessment of the Safety, Tolerability and Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules. Identifier: NCT01226316

For more information, please contact:

Astex Therapeutics Ltd

Jeremy Carmichael, PhD

Director of Business Development

Tel: +44(0)1223 226200


Press & Media Enquiries

College Hill

(Europe) Melanie Toyne Sewell / Daniel Gooch

Tel: +44 20 7866 7866

(US) Rebecca Skye Dietrich

Tel: +1 857 241 0795


About Astex Therapeutics

Astex is a UK-based biotechnology company that discovers and develops novel small molecule therapeutics. Using its pioneering fragment-based drug discovery platform Pyramid™, Astex has built a pipeline of molecularly-targeted oncology drugs, of which three are currently being tested in clinical trials with others in discovery and pre-clinical development.

In addition to its proprietary research programmes, Astex’s productivity in lead discovery has been endorsed through numerous partnerships with major pharmaceutical companies, including AstraZeneca, GlaxoSmithKline, Johnson & Johnson and Novartis.

For further information on Astex please visit the Company’s website at

Read at

comments powered by Disqus