Hardware and Software Solution co-developed with inviCRO Provides New
Multi-Modality Insights into Luminescence-based In Vivo Imaging
TORONTO, ON, SHOHAM, Israel, and BOSTON, MA, April 8, 2013 /PRNewswire/ -
Aspect Imaging, the leader in compact, high-performance permanent
magnet systems, today announced LumiQuant, its software and hardware solution for co-registering and measuring
luminescence imaging images with the Bruker ICON compact
high-performance MRI system. The LumiQuant solution enables researchers
to generate 3D luminescence data co-registered with MRI, representing a
novel path forward in multi-modal tomographic imaging. LumiQuant
leverages a multi-modality cassette that allows a mouse to be imaged in
an optical instrument and then moved and imaged in the Bruker ICON
compact MRI without perturbation. LumiQuant is called as a routine from
inviCRO's VivoQuant software. The image reconstruction and
co-registration package uses a proprietary set of algorithms to create
a three-dimensional distribution of luminescence signal. Luminescence,
which is the most widely used pre-clinical in vivo imaging modality for assessing pre-clinical disease models, suffers
from the physical constraints of the absorption and scattering of light
in tissues. This absorption and scattering hinders the ability of
luminescence systems to differentiate between luminescence signal in
different organs and on the surface or signal deep within the tissue
and therefore limits the researcher's ability to tell whether a
luminescence-expressing tumor, for example, is on the surface, is deep
in the organ, is a single tumor mass or possibly is the signal
expressed from multiple lesions at different positions in the body.
LumiQuant seeks to resolve this obstacle through enhanced insights and
quantitation of 3D luminescence/MR imaging and disease phenotyping.
"Aspect Imaging's goal is to develop and commercialize MRI-based
technologies to reduce the cost and complexity associated with
conventional MR systems while enabling powerful results and new
insights," says Uri Rapoport, Aspect Imaging's Founder and CEO. "LumiQuant can be an excellent tool for the thousands of luminescence imagers
worldwide to extend the capabilities of a single modality to quickly
gain anatomical reference - - through co-registration with compact MRI
data from the Bruker ICON system - - and increased precision of their
insights. The end goal is an increase in the characterization of their
biomarkers of interest".
VivoQuant and LumiQuant software are optimized for use on the Bruker
ICON compact MRI system and Aspect Imaging's novel compact,
high-performance MRI is powering the Bruker ICON platform, the leading
pre-clinical compact MRI system worldwide.
"VivoQuant is a leading software platform for pre-clinical imaging
post-processing and quantification and we are thrilled to be working
with Aspect Imaging to leverage the inherent tomographic benefits of
compact MRI to enhance the insights possible with luminescence
imaging", says Jack Hoppin, Ph.D., Co-founder and Managing Partner of
inviCRO. "With LumiQuant,there is now an exciting platform that enables 3D luminescence using
co-registration with the ICON compact MRI system that has the potential
to understand tumor cell proliferation outside of the limited
subcutaneous xenograft environment".
Results from initial testing on LumiQuant will be presented by Matt
Silva, Ph.D., Director, Imaging Research, InviCRO at the Aspect
Imaging/Bruker ICON In Vivo Imaging Workshop, titled "Quantification of Pre-Clinical Cancer Phenotyping using Novel Compact
High-Performance MRI" on Monday, April 8, 2013 at the Renaissance Hotel, Washington, DC.
The LumiQuant solution will also be demonstrated at the American
Association of Cancer Research's Annual Meeting 2013 at the Walter E. Washington Convention Centre in Washington, DC, April
6 - 12, 2013 at the Bruker ICON booth #702 in the Exhibit Hall.
About Aspect Imaging:
Aspect Imaging(www.aspectimaging.com)is the world's leader in the design and development of high-performance
compact MRI imaging systems for pre-clinical, clinical and advanced
industrial applications. In the clinical market, Aspect Imaging has multiple clinical programs underway including its
system to provide highly efficient just-in-place compact MRI for
imaging of the wrist. In the pre-clinical research market, Aspect
supplies its M2 magnet, gradients and handling systems to Bruker for
use in its leading ICON compact MRI platform. Due to its high-performance M2 permanent magnet and suite of related
products, the ICON enables academic researchers and pharmaceutical
companies to harness the power and insights of MRI but without the
cost, complexity and technical burden of traditional MRI systems.
Pre-clinically, Aspect's M2 system is also used for providing 3D MR-based Histology to compliment and direct pathology and histology-based analysis as well
as providing the M2 platform to Mediso Medical Systems for use in its nanoScan® integrated PET/MRI and SPECT/MRI systems. Aspect Imaging's novel
permanent magnets are also used in advanced industrial applications
including rheology where its MicroFlow platform can operate inline on large-scale production lines for food
processing, consumer products, biofuels and other applications
providing real-time, non-invasive and quantitative read-outs for
process and quality control.
inviCRO (www.invicro.com) was founded with a mission of improving the value of imaging in drug
discovery and development. inviCRO provides a full range of services
and software solutions for pre-clinical imaging and novel translational
work including contract research, custom data analysis, and software
programs for image analysis, data management and high-throughput image
processing. Their experienced team of 25+ scientists possesses unique
capabilities in imaging physics, advanced biostatistics,
multi-dimensional image processing, software development and an
intimate understanding of imaging systems, agents and animal models.
Managing and/or processing more than fifteen imaging studies per month
across a broad range of applications, inviCRO has processed over 35,000
tomograms over the past three years. inviCRO's analysis and management
software is used in over 100 imaging facilities worldwide and growing.
SOURCE Aspect Imaging