BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

ApoCell, Inc. Receives $1 Million SBIR Contract To Develop A Point-of-Care Clinical Device For Circulating Tumor Cell (CTC) Isolation


11/13/2013 9:43:08 AM

free biotech news Get the latest biotech news where you want it. Sign up for the free GenePool newsletter today!

HOUSTON, TX--(Marketwired - November 13, 2013) -

ApoCell, Inc. announced that it has been awarded a two-year Small Business Innovation Research (SBIR) Phase II contract from the National Cancer Institute (NCI) for the further development of its ApoStream® technology as a point-of-care (POC) clinical device to isolate circulating tumor cells (CTCs) from human blood. The $1 million provided by the NCI under this Phase II program will cover 100% of the project costs. Isolating CTCs from a small sample of a patient's whole blood enables downstream biomarker and molecular analysis that can provide information for cancer diagnosis and treatment decisions.

Houston-based ApoCell was invited to apply for this latest grant after successfully completing its SBIR Phase I contract which included investigation and demonstration of the potential to use the ApoStream® technology in a POC setting.

CTCs have long been known to exist in cancer patients' blood and clinical correlations have been established between CTC counts and disease progression. These circulating cells represent an increasingly attractive target for clinicians seeking to assess a patient's disease state; however, the clinical promise of CTCs has yet to be fully realized because they are difficult to isolate using the commercially available technologies. ApoStream® utilizes antibody-independent dielectrophoresis (DEP) in a continuous flow process, to enrich significant quantities of intact CTCs from a wide range of cancer types, enabling more robust downstream analysis for greater understanding of each patient's disease. The company plans to commercially launch the technology for research-use-only in 2014 and as a point-of-care clinical device in 2016.

"This SBIR Phase II funding will significantly enhance our progress in developing ApoStream® as a point-of-care clinical device," said Darren Davis, president and CEO of ApoCell. "We believe the device, which uses an antibody-independent isolation process, can play a significant role in the evolution of personalized cancer treatment through the downstream analysis of a patient's CTCs."

Davis said the latest SBIR funding will support research and development efforts that include enhancing ApoStream®'s ease of use, overall system performance and further automation of quality control.

The SBIR Phase II funding will also support further research to demonstrate clinical utility through the detection of gene mutation in CTCs collected from the blood samples of non-small cell lung cancer patients. A study co-authored by investigators from University of Texas M.D. Anderson Cancer Center, and presented by poster at the 2013 ASCO annual meeting, utilized ApoStream® technology in isolating CTCs from 32 non-small cell lung cancer patients and 3 healthy volunteers to identify and characterize specific EGFR mutations, with the goal of determining the concordance of mutations between blood and tumor tissue.

A leader in molecular biomarker detection and analysis, ApoCell has been using ApoStream® technology since 2010 in its own laboratories and has incorporated it into 20 early and late stage clinical trials as part of the company's service offering.

For more information on ApoStream technology and ApoCell, visit www.apocell.com.

About ApoCell

Based in Houston, ApoCell (www.apocell.com) is a privately-held specialty clinical research company. Founded in 2004, the firm is a leader in molecular biomarker detection and analysis, leveraging its expertise in the areas of oncology, diabetes, molecular diagnostics and drug development to measure biomarker signatures in clinical trial subjects. The company's proprietary methods provide early proof of mechanism of action and monitor the effectiveness of various types of drugs by measuring biomarker expression patterns in biopsies, blood and rare cell types. The company's facilities are CLIA-certified and compliant with applicable FDA regulations. Since inception, the company has participated in over 140 Phase I, II, and III clinical cancer drug trials for more than 80 sponsor clients worldwide.


Contacts:

Cherri Carbonara
Carbonara Group
cherri@carbonaragroup.com
(o) 713-524-8170

or

Lori Pennington
Carbonara Group
lori@carbonaragroup.com
(o) 713-524-8170



Help employers find you! Check out all the jobs and post your resume.


Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES