BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Apeiron Biologics Acquires Option to License Rights to Novel Oncology Compounds from Cleveland Clinic


3/15/2011 10:28:55 AM

Vienna (Austria)/Cleveland (USA), 15 March 2011 - APEIRON Biologics AG announced that it has entered into an exclusive option to license from the Cleveland Clinic a number of novel compounds. These compounds are currently in development at Cleveland Clinic as drug candidates for treatment of various cancers, designed to fight cancer based on stimulation of the immune system. In preclinical models, they have shown anti-cancer activity and a favourable toxicity profile as orally available agents. This transaction follows in the wake of successful in-licensing deals that Apeiron completed in the last six months.

Apeiron Biologics AG, Vienna (Austria) and Cleveland Clinic Foundation, Cleveland (USA), have entered into a set of agreements setting the framework for a collaboration on novel anti-cancer compounds currently in development at Cleveland Clinic. The collaboration includes an option to Apeiron to enter into a worldwide, exclusive license agreement with the Clinic relating to the compounds, and an Apeiron sponsored research agreement with the Clinic relating to these compounds and approach.

The compounds, tyrosine phosphatase inhibitors (TPI), have been designed to inhibit SHP-1, a protein tyrosine phosphatase, which is a key negative regulator of immune cell activation. Inhibition of SHP-1 leads to activation of the immune system to combat cancer.

Commenting on the agreements, Hans Loibner, CEO of Apeiron, said: "This is a great collaboration for Apeiron. We regard the compounds developed at Cleveland Clinic as an attractive opportunity since they are designed to activate the patient's own immune system." He added: "Cleveland Clinic is a leading R&D institution and one of the top hospitals in the US."

"We have been encouraged by the developments we have seen in regards to these novel compounds, and we hope these therapeutics will one day benefit patients," said Chris Coburn, Executive Director of Cleveland Clinic Innovations.

No financial details are disclosed.

About Apeiron (March 2011):

Apeiron Biologics AG is a privately financed Biotech company based in Vienna. Following a licensing deal with GSK in 2010 relating to project APN01 (recombinant human Angiotensin Converting Enzyme 2, rhACE2), Apeiron expanded its project portfolio with a focus on biologic / immunologic therapy of cancer and related conditions. Building on an existing range of innovative in-house projects, Apeiron acquired exclusive rights to hu14.18-IL2 (APN301), a Phase II antibody-based biologic for treatment of neuroblastoma, melanoma and other cancers, and recombinant human Superoxide Dismutase (APN201), a naturally occurring enzyme for treatment of cancer treatment-related side-effects, also in Phase II.

Contact Apeiron:

Dr. Hans Loibner, CEO Campus-Vienna-Biocenter 5 1030 Vienna, Austria T +43 / 1 / 865 6577 E apeiron@apeiron-biologics.com W www.apeiron-biologics.com

Copy Editing & Distribution for Apeiron:

PR&D - Public Relations for Research & Education Mariannengasse 8 1090 Vienna, Austria T +43 / 1 / 505 70 44 E contact@prd.at W www.prd.at

Dechert LLP acted as legal advisor to Apeiron.

Mag. Maria Fraczek PR-Assistentin & Office Managerin

PR&D - Public Relations for Research & Education

T +43 1 505 70 44 F +43 1 505 50 83 E fraczek@prd.at

Mariannengasse 8 1090 Vienna, Austria

http://www.prd.at



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES