Animal Study Leading to New Treatments for Hemorrhagic Shock and Uncontrolled Abdominal Hemorrhage
Blood loss due to severe internal injuries requires rapid action to prevent mortality. Using a swine model for severe hemorrhagic shock and uncontrolled abdominal hemorrhage, three methods of treatment were investigated. In a paper to be presented at the 2007 Society for Academic Emergency Medicine (SAEM) Annual Meeting, James Manning, MD, will show that Hemoglobin-Based Oxygen Carrier (HBOC)-201 resuscitation maintained survival longer than Hetastarch, and in particular, targeting a Mean Arterial Pressure (MAP) of 80 mm Hg was more favorable than a target MAP of 100 mm Hg.