AnaSpec, Inc. Introduces SensoLyte® Factor Xa Activity Assays - Industry's First Fluorimetric Kits
Key highlights for AnaSpec’s new SensoLyte® Factor Xa Assay Kits:
• Kits optimized to detect Factor Xa enzyme activity
• Fluorometric, long wavelength (Ex/Em=490/520 nm) read-out assays
• Minimal autofluorescence
• Kits provide ample reagents to perform 100 assays in a 96-well plate format
• Assays can be completed in one hour
Factor Xa (FXa) is a serine endopeptidase composed of two disulfide-linked subunits. FXa leads to blood clot formation by converting prothrombin to thrombin through the prothrombinase complex. FXa is generated from zymogen Factor X via the intrinsic and extrinsic pathways and is the rate-limiting step in the propagation of thrombin generation. In the presence of Ca2+ ions, FXa forms prothrombinase with factor Va on the phospholipid membrane of the activated platelets.1-3 FXa has emerged as an attractive target for drug discovery for thromboembolic diseases.4,5
Reference
1. Furie, B. and Furie, BC. Cell 53:505–518 (1988).
2. Davie, EW. et al. Biochemistry 30:10363–10370(1991).
3. Mann, KG. Thromb Haemost 82:165-174 (1999).
4. Camm, AJ. and Bounameaux, H. Drugs 71:1503-1526 (2011).
5. Weitz, JI. Thromb Res 127 Suppl 2:S5-S12 (2011).
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AnaSpec, Eurogentec Group
AnaSpec, Eurogentec Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.
For more information visit www.anaspec.com