AnaSpec, Inc. Introduces Pancreatic ß-Cells Specific Antibodies - Anti-hFXYD2?a

Fremont CA – March 19, 2012 -- AnaSpec, EGT Group is pleased to announce the release of three antibodies (two monoclonal and one polyclonal) against FXYD2?a. FXYD2?a is a regulating subunit of the NA+-K+-ATPase and has been identified as a unique and specific pancreatic beta cell surface biomarker. In individuals with Type 1 diabetes or in pancreatic sections of streptozotocin-treated Macacus cynomolgus monkeys, loss of FXYD2?a has been closely correlated with a loss of insulin positive cells.1

Anti-hFXYD2?a antibodies are purified antibodies reacting with an 11 amino acid residue peptide of FXYD2?a. Monoclonal anti-FXYD2?a antibodies from Clone 4F9G9 show high specificity towards FXYD2?a beta-cell biomarker while monoclonal anti-FXYD2?a antibodies from Clone 3C1D10 show high sensitivity towards FXYD2?a beta-cell biomarker. A rabbit polyclonal anti-hFXYD2?a antibody is also available (see Table 1). These antibodies can be used for beta cell specific targeting and non-invasive imaging. The use of targeting strategies against the biomarker (FXYD2?a) allows early identification of beta cell and the follow up of therapies for diabetes patients.

Reference

1. Flamez, D. et al. Diabetologia. 2010 Jul.53(7):1372-83.

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AnaSpec, EGT Group

AnaSpec, Eurogentec Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.

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