BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

AnaptysBio, Inc. Describes Technology for the Discovery and Optimization of Fully Human Antibodies in Original Research Publication


12/6/2011 9:12:36 AM

SAN DIEGO, Calif., Dec. 5, 2011 /PRNewswire/ -- AnaptysBio, Inc., a privately-held therapeutic antibody company, today announced the publication of original research describing the discovery of novel fully-human antibodies against human nerve growth factor (NGF) using AnaptysBio's SHM-XEL platform in the Proceedings of the National Academy of Sciences (PNAS).

(Logo: http://photos.prnewswire.com/prnh/20111205/SF16052LOGO)

Entitled "Coupling Mammalian Cell Surface Display with Somatic Hypermutation for the Discovery and Maturation of Human Antibodies", Dr. David J. King, chief scientific officer of AnaptysBio, and colleagues describe the identification of multiple anti-NGF specific antibodies from AnaptysBio's proprietary fully-human antibody libraries followed by in vitro somatic hypermutation (SHM) in mammalian cells to generate low picomolar affinity lead candidates. This platform methodology, known as SHM-XEL, replicates key features of the human immune system and overcomes key limitations of prior antibody technologies. By reproducing the natural mechanism of antibody maturation under controlled conditions outside of the constraints of an in vivo environment, this platform allows selection of optimal antibody properties such as high affinity, functionality, cross-reactivity and epitope diversity. The use of mammalian cell display permits AnaptysBio to also optimize manufacturing-related parameters by selecting for high-level expression and stability in parallel. Simultaneous secretion of antibody variants by the mammalian cells utilized during SHM-XEL permits incorporation of functional assays in the antibody discovery process. In addition to the "hot-spot" motif point mutations associated with SHM, this article also demonstrates that SHM-XEL further replicates the diversity of the immune system by mediating nucleotide insertions and deletions in the antibody variable domain.

"Our SHM-XEL platform uniquely combines in vitro SHM with mammalian cell display to overcome the technical limitations faced by traditional mouse administration and phage display methodologies," said Carol G. Gallagher, executive chairman of AnaptysBio. "We will continue to utilize this platform to discover novel antibodies for AnaptysBio's internal pipeline and with strategic partners looking to utilize our team and technology to expand their antibody discovery capabilities."

NGF has recently been validated as a therapeutic target for the treatment of various pain conditions associated with tissue injury and inflammation. NGF leads to the activation of various intracellular pathways that enhance acute and chronic pain sensations. Antagonism of NGF binding has been shown in animal and clinical studies as a potent treatment for pain.

About AnaptysBio

Founded in 2005, AnaptysBio, Inc. is a privately-held company focused on the generation of antibody therapeutics, and the leader in the use of somatic hypermutation (SHM) for antibody discovery and optimization. SHM is the body's natural process for generating potent antibodies. The Company's SHM-XEL platform couples SHM with mammalian cell display to generate antibodies for therapeutic applications through an iterative process of natural evolution and high-throughput selection under controlled conditions a process that has been referred to as "naturalizing" antibodies. This versatile platform can be used for both discovery of new antibodies and optimization of existing antibodies to generate candidates with desired properties for therapeutic applications. AnaptysBio has established broad intellectual property around the use of SHM, and is currently building a pipeline of novel therapeutic antibody product candidates. Major investors in AnaptysBio include founding investor Avalon Ventures, as well as Alloy Ventures, Frazier Healthcare Ventures, and Novo A/S. For more information, visit www.anaptysbio.com.

Contact:

Hamza Suria

hsuria@anaptysbio.com

858-362-6383

SOURCE AnaptysBio, Inc.



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES