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Alnylam Pharmaceuticals (ALNY) and Collaborators Publish Scientific Paper Documenting Discovery of Second Generation MC3 Lipid Nanoparticles (LNPs)


7/13/2012 10:21:47 AM

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and collaborators announced today the publication of a scientific paper documenting the discovery of novel lipids used in second generation lipid nanoparticles (LNPs) for systemic delivery of RNAi therapeutics. These results were published in a paper titled “Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo” (DOI: 10.1002/anie.201203263) in the journal Angewandte Chemie International Edition. The findings describe the rational design, synthesis, and evaluation of novel lipids, including MC3, that have led to the discovery of Alnylam’s proprietary second generation LNP platform for systemic delivery of RNAi therapeutics. This research was conducted in collaboration with scientists from AlCana Technologies, Inc. and the University of British Columbia (UBC).

Read at BioSpace.com


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