AUSTIN, March 15 /PRNewswire/ - Affinium Pharmaceuticals, a clinical-stage drug
development company with a novel, specific-spectrum anti-staphylococcal
antibiotic, announced today that Dr. Barry Hafkin, Chief Medical
Officer, and Dr. Nachum Kaplan, Vice President of Microbiology, will
present at the 13th Annual Super Bugs and Super Drugs conference in London, England on
March 16-17, 2011.
Dr Kaplan will be speaking on development of a novel, specific-spectrum,
oral antibiotic for staphylococcal infections at 2:10 pm GMT on
Thursday, March 17. Dr. Hafkin will moderate and participate in the
panel discussion on the challenges facing antibiotic drug developers
and lessons learned from recent antibiotic regulatory approvals at 4:10
pm GMT on Thursday, March 17, 2011.
Over the past two decades, Superbugs and Superdrugs has become an
industry-leading conference on antibiotics and resistant organisms. The
conference tackles crucial issues surrounding anti-infective drug
development and the emergence of multi-resistant organisms. Visit http://www.smi-online.co.uk/events/overview.asp?is=4&ref=3444 for more information.
About Affinium Pharmaceuticals
Affinium Pharmaceuticals is a specialty pharmaceutical company focused
on development of novel anti-infective medicines based on the FASII
pathway. The Affinium FASII antibacterial programs constitute a new
antibiotic franchise with the potential for multiple products. These
programs include a broad base of long-term intellectual property:
issued and pending composition of matter patents on potent orally
available small molecule inhibitors of a new class of antibiotics with
a unique mechanism of action, targeting an underexploited pathway. AFN-
1252 is the lead candidate from the program.
AFN-1252, the lead clinical candidate from Affinium's FASII program, is
designed to selectively target the staphylococcal FabI enzyme. AFN-1252
provides exceptional nanomolar potency against all drug-resistant
phenotpyes of staphylococci, including hospital- and community-acquired
methicillin-resistant Staphylococcus aureus (MRSA) and
coagulasenegative staphylococci. Extremely low propensity for microbial
resistance development has been observed in microbiological studies.
The antibiotic has also shown excellent in vivo efficacy in animal
models of infection. Oral bioavailability and excellent safety &
tolerability have been demonstrated in three Phase 1 single- and
multiple-ascending dose clinical trials and in human microdosing
studies. An injectable formulation is advancing through pre-clinical
SOURCE Affinium Pharmaceuticals