Afferent Pharmaceuticals Reports Positive Phase 2 Clinical Data for the Company’s Lead P2X3 Antagonist, AF-219

BARCELONA, Spain--(BUSINESS WIRE)--Afferent Pharmaceuticals today announced positive clinical efficacy results from the Phase 2 study of the Company’s first-in-class oral P2X3 antagonist, AF-219, in patients with treatment-refractory chronic cough. Afferent is a clinical-stage biopharmaceutical company leading the development of first-in-class, proprietary, small molecule compounds that target P2X3 receptors for the treatment of chronic pain, respiratory and urological conditions. In a randomized, double-blind, placebo-controlled, crossover Phase 2 clinical study, AF-219, dosed orally twice daily, was demonstrated to markedly reduce daytime cough frequency by an unprecedented 75% at week 2 of treatment (as measured using an ambulatory sound monitoring system) in patients with treatment-refractory chronic cough (p< 0.001). The study results were featured today in a late-breaking oral presentation titled, “Inhibition of ATP-gated P2X3 channels by AF-219: An effective anti-tussive mechanism in chronic cough” (Abstract No. 1965), at the European Respiratory Society (ERS) Annual Congress 2013, which is taking place in Barcelona, Spain, September 7 - 11, 2013.

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