BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Adenosine Therapeutics Awarded Phase II SBIR Grant To Treat Asthma And STTR Grant To Develop New Treatment For Sepsis


10/26/2006 10:36:47 AM

CHARLOTTESVILLE, Va., Oct. 26 /PRNewswire/ -- Adenosine Therapeutics, LLC, a leading adenosine drug discovery and development company, announced today it has been awarded 4 new grants totaling approximately $1,887,634. These grants are to further evaluate new therapeutic approaches for the treatment of asthma, sepsis, and arthritis.

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, funded the grants: a Phase II Small Business Innovation Research (SBIR) grant for $755,496 to identify an A2BR antagonist as a therapeutic candidate for the treatment of asthma; a Phase I Small Business Technology Transfer Research Advanced Technology (STTR-AT) grant for $861,737 to further expand its research on the use of apadenoson, the Company's selective A2A agonist that is in Phase III clinical testing as a heart imaging agent, for the treatment of sepsis (systemic bacterial infection); a Phase I Small Business Technology Transfer Research (STTR) grant for $132,798 to further expand its pre-clinical research on the use of agents that activate the adenosine A2A receptor subtypes for the treatment of S. aureus (or gram positive) sepsis; and a Phase I STTR for $137,603 to further expand its clinical research on the use of agents that activate the adenosine A2A receptor subtypes for the treatment of arthritis.

The goal of the asthma grant is to develop a selective blocker of the adenosine A2B receptor (A2BAR) that could replace theophylline, a non-selective adenosine blocker, in the treatment of asthma.

Chemists at Adenosine Therapeutics, LLC have synthesized a new series of proprietary selective adenosine A2B receptor blockers and have identified compounds that have potential for further development as clinical candidates. The goal of the studies sponsored by the SBIR funding is to advance a lead candidate for clinical development.

"We are excited about the opportunity to develop a new tool for the treatment of asthma, a disease that affects over 9 million adults and 5 million children in the US," said Robert Capon, CEO and co-founder of ATL. "An alternative that minimizes the side effects common with current treatment would add a powerful new tool to treat this illness."

The sepsis grant awards will accelerate research on apadenoson and other compounds owned by the Company for the possible treatment of sepsis. Sepsis is a life-threatening condition affecting over half a million people in the US annually. There has been a dramatic increase in the incidence of sepsis over the last 20 years and physicians have limited therapies available for its treatment.

"With a mortality rate in severe sepsis of over 30% and only a limited number of therapeutic agents available, sepsis represents a major unmet medical need," said Shannon P. Williams, PhD, Principal Investigator and Vice President Regulatory and Clinical Development at ATL. "Apadenoson represents an important new potential tool for the treatment of sepsis patients."

The arthritis grant award will further Adenosine Therapeutics' development of a second generation of A2A agonists for the treatment of chronic inflammatory conditions such as arthritis.

About Adenosine Therapeutics

Adenosine Therapeutics focuses on the discovery and development of novel pharmaceutical products that selectively target the four known adenosine receptor subtypes. Candidates for drug development are identified and screened using the company's state-of-the-art adenosine receptor screening platform technology. The company was founded with the goal of taking new adenosine- receptor selective drugs into clinical trials for a broad range of potential indications. These drug indications include inflammatory indications, sepsis, heart attack, ischemia-reperfusion injury, vascular injury, spinal cord injury, COPD, asthma, diabetes, obesity, inflammatory bowel disease, retinopathy, and Parkinson's disease. The company's most advanced drug development program is in Phase III clinical development. For more information on Adenosine Therapeutics, please visit our web site at http://www.adenrx.com.

Adenosine Therapeutics, LLC

CONTACT: Robert Capon of Adenosine Therapeutics, LLC, +1-434-220-9400 x201



Read at BioSpace.com

   
Sepsis

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES