GHENT, BELGIUM--(Marketwire - April 25, 2012) - Ablynx [Euronext Brussels: ABLX] today
that Boehringer Ingelheim has submitted a Clinical Trials Application
the European regulatory authorities to start a Phase I clinical trial
Nanobody® for the treatment of Alzheimer's disease. The
Nanobody has been
developed as part of the collaboration signed between Ablynx and
the event triggers a EUR1 million milestone payment to Ablynx.
In January 2007, Boehringer Ingelheim and Ablynx announced a worldwide
and licensing agreement to discover and develop new therapies for
disease using Ablynx's Nanobodies against a single disease target.
collaboration has a potential value of $265 million in upfront and
payments plus undisclosed royalties on product sales. Boehringer
solely responsible for the development, manufacturing and
any products resulting from the collaboration.
Dr Edwin Moses, CEO and Chairman of Ablynx, commented:
"We are excited that Boehringer Ingelheim has already submitted a CTA for
Nanobody. This development candidate has the potential to be a first-in-
therapy for Alzheimer's disease and demonstrates the power of our
platform. We look forward to seeing this programme enter the clinic
About Alzheimer's disease
Alzheimer's disease is the most common form of dementia in adults.
estimated to affect 4.5 million Americans and over 30 million people
with an average course of 8-12 years. It is projected that the
prevalence will double over the next 20 years. Marketed products address
the symptoms, but there are currently no treatments available that delay or
the progression of the disease. Global sales of Alzheimer's disease drugs
approximately $8 billion in 2010 and are expected to exceed $14 billion by
Ablynx is a biopharmaceutical company engaged in the discovery and
of Nanobodies(®), a novel class of therapeutic proteins based on
antibody fragments, for a range of serious and life-threatening human
including inflammation, haematology, oncology and pulmonary disease.
Company has over 25 programmes in the pipeline and seven Nanobodies at
development stage. Ablynx has ongoing research collaborations and
partnerships with major pharmaceutical companies, including
Ingelheim, Merck Serono and Novartis. The Company is headquartered in
Belgium. More information can be found on www.ablynx.com.
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Source: Ablynx via Thomson Reuters ONE