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Ablynx and Merck Serono Select a Novel Nanobody Candidate, ALX-0761, for Pre-Clinical Development


12/13/2011 8:50:38 AM

GHENT, BELGIUM--(Marketwire - December 12, 2011) - Ablynx [Euronext Brussels: ABLX] and partner Merck Serono, a division of Merck KGaA, Darmstadt, Germany, today announced that they have advanced the Nanobody candidate, ALX-0761, into pre- clinical development for the treatment of autoimmune diseases. This is the first pre- clinical candidate that has emerged from the collaboration which the companies entered in 2008, and will result in a EUR1 million milestone payment to Ablynx.

In September 2008, Ablynx entered into an agreement with Merck Serono under which Merck Serono and Ablynx co-discover and co-develop Nanobodies against two targets in immunology and oncology. The agreement included an upfront cash payment to Ablynx of EUR10 million and both companies will share equally all research and development costs and the resulting profits. Ablynx has options to opt-out during the research and development programmes, in which case Ablynx would be eligible to receive milestones and royalties.

In October 2010, Ablynx and Merck Serono entered into a second co- discovery and co-development agreement to develop Nanobodies against one single target in inflammation. Ablynx received an upfront fee of EUR10 million and retained full control to drive the process up to the investigational new drug (IND) upon which it is eligible to receive a EUR15 million success fee provided that Merck Serono accepts the IND package. This agreement also allows Ablynx to continue with Merck Serono on a co-development basis and share the resulting profits, or to convert this collaboration into a licensing deal with milestone payments and significant tiered royalties.

"We are very pleased to see our first joint immunology programme with Merck Serono advancing into pre-clinical development just three years since the start of our collaboration," said Dr. Edwin Moses, Chairman and CEO of Ablynx. "It demonstrates the speed at which our Nanobody platform can generate lead candidates for further development and we are looking forward to eventually entering the clinic with this programme in partnership with Merck Serono."

Complete version of the press release: http://hugin.info/137912/R/1570501/488377.pdf

This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients. The owner of this announcement warrants that: (i) the releases contained herein are protected by copyright and other applicable laws; and (ii) they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: Ablynx via Thomson Reuters ONE

[HUG#1570501]


For more information, please contact Ablynx:
Dr Edwin Moses
Chairman and CEO
t: +32 (0)9 262 00 07
m: +44 (0)7771 954 193 /
+32 (0)473 39 50 68
e: Email Contact

Marieke Vermeersch
Investor Relations Manager
t: +32 (0)9 262 00 82
m: +32 (0)479 49 06 03
e: Email Contact


Read at BioSpace.com


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