A Potential Novel Drug-Target for Colorectal Cancer Treatment Comes From the Brain, Federal University of Rio Grande do Sul Study

EurekAlert! -- Porto Alegre, Brazil- Tumor progression is usually ensured by more than one proliferative mechanism. When one of these is shut down by a specifically targeted drug, other mechanisms may emerge. While these events may lead to treatment failure, they may also become an opportunity for researchers to identify novel targets to be further explored. In a paper recently published in the journal Oncology ("BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer," Vol. 79, pages 430-439, 2011; DOI: 10.1159/000326564) Roesler and colleagues describe a novel potential drug-target in colorectal cancer.